A polymorphism of the GTP-cyclohydrolase I feedback regulator gene alters transcriptional activity and may affect response to SSRI antidepressants

Keyphrases

• Transcriptional Activity 100%
• Polymorphism 100%
• GTP Cyclohydrolase I 100%
• Selective Serotonin Reuptake Inhibitor Antidepressant 100%
• Affect Responses 100%
• Feedback Regulators 100%
• Regulatory Genes 100%
• BH 4 100%
• Neurotransmitters 66%
• Antidepressants 66%
• Regression Analysis 33%
• Mood Disorders 33%
• Biological Processes 33%
• Luciferase Reporter Assay 33%
• Major Depressive Disorder 33%
• Serotonin 33%
• Single nucleotide Polymorphism 33%
• Serotonergic System 33%
• Tetrahydrobiopterin 33%
• Transcription Rate 33%
• Fluoxetine 33%
• Promoter Variants 33%
• Nortriptyline 33%
• Tricyclic Antidepressants 33%
• Serotonergic Neurons 33%
• Selective Serotonin Reuptake Inhibitors 33%

Neuroscience

• Antidepressant 100%
• Regulator Gene 100%
• Selective Serotonin Reuptake Inhibitor 100%
• GTP Cyclohydrolase I 100%
• Haplotype 75%
• Promoter Region 50%
• Neurotransmitter 50%
• Serotonergic 50%
• Major Depressive Disorder 25%
• Single-Nucleotide Polymorphism 25%
• Mood Disorder 25%
• Sapropterin 25%
• Reporter Gene 25%
• Serotonin 25%
• Cofactor 25%
• Nortriptyline 25%
• Tricyclic Antidepressant 25%
• Fluoxetine 25%
• Luciferase 25%