A Reversible Inhibitor of P-Lactamase I from Bacillus cereus

Mark Jones; Stephen C. Buckwell; Michael I. Page; Roger Wrigglesworth

doi:10.1039/C39890000070

A Reversible Inhibitor of P-Lactamase I from Bacillus cereus

Mark Jones, Stephen C. Buckwell, Michael I. Page, Roger Wrigglesworth

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

α-Methyl (3S,5R,6R)benzylpenicilloate is a reversible competitive inhibitor of β-lactamase l from Bacillus cereus; the inhibition constant K_i is 6.38 × 10^-4M and is independent of pH between pH 5 and 8 which is compatible with binding of the free base form of the thiazolidine residue to the enzyme.

Original language	English
Pages (from-to)	70-71
Number of pages	2
Journal	Journal of the Chemical Society, Chemical Communications
Issue number	2
DOIs	https://doi.org/10.1039/C39890000070
Publication status	Published - Jan 1989

Access to Document

10.1039/C39890000070

Link to publication in Scopus

Fingerprint Dive into the research topics of 'A Reversible Inhibitor of P-Lactamase I from Bacillus cereus'. Together they form a unique fingerprint.

Cite this

@article{cb8e118f80f24e86816157b61820aeb5,

title = "A Reversible Inhibitor of P-Lactamase I from Bacillus cereus",

abstract = "α-Methyl (3S,5R,6R)benzylpenicilloate is a reversible competitive inhibitor of β-lactamase l from Bacillus cereus; the inhibition constant Ki is 6.38 × 10-4M and is independent of pH between pH 5 and 8 which is compatible with binding of the free base form of the thiazolidine residue to the enzyme.",

author = "Mark Jones and Buckwell, {Stephen C.} and Page, {Michael I.} and Roger Wrigglesworth",

year = "1989",

month = jan,

doi = "10.1039/C39890000070",

language = "English",

pages = "70--71",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

number = "2",

}

TY - JOUR

T1 - A Reversible Inhibitor of P-Lactamase I from Bacillus cereus

AU - Jones, Mark

AU - Buckwell, Stephen C.

AU - Page, Michael I.

AU - Wrigglesworth, Roger

PY - 1989/1

Y1 - 1989/1

N2 - α-Methyl (3S,5R,6R)benzylpenicilloate is a reversible competitive inhibitor of β-lactamase l from Bacillus cereus; the inhibition constant Ki is 6.38 × 10-4M and is independent of pH between pH 5 and 8 which is compatible with binding of the free base form of the thiazolidine residue to the enzyme.

AB - α-Methyl (3S,5R,6R)benzylpenicilloate is a reversible competitive inhibitor of β-lactamase l from Bacillus cereus; the inhibition constant Ki is 6.38 × 10-4M and is independent of pH between pH 5 and 8 which is compatible with binding of the free base form of the thiazolidine residue to the enzyme.

UR - http://www.scopus.com/inward/record.url?scp=0024576827&partnerID=8YFLogxK

U2 - 10.1039/C39890000070

DO - 10.1039/C39890000070

M3 - Article

AN - SCOPUS:0024576827

SP - 70

EP - 71

JO - Chemical Communications

JF - Chemical Communications

SN - 1359-7345

IS - 2

ER -