A Reversible Inhibitor of P-Lactamase I from Bacillus cereus

Mark Jones, Stephen C. Buckwell, Michael I. Page, Roger Wrigglesworth

Research output: Contribution to journalArticle

5 Citations (Scopus)


α-Methyl (3S,5R,6R)benzylpenicilloate is a reversible competitive inhibitor of β-lactamase l from Bacillus cereus; the inhibition constant Ki is 6.38 × 10-4M and is independent of pH between pH 5 and 8 which is compatible with binding of the free base form of the thiazolidine residue to the enzyme.

Original languageEnglish
Pages (from-to)70-71
Number of pages2
JournalJournal of the Chemical Society, Chemical Communications
Issue number2
Publication statusPublished - Jan 1989


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