Abstract
α-Methyl (3S,5R,6R)benzylpenicilloate is a reversible competitive inhibitor of β-lactamase l from Bacillus cereus; the inhibition constant Ki is 6.38 × 10-4M and is independent of pH between pH 5 and 8 which is compatible with binding of the free base form of the thiazolidine residue to the enzyme.
| Original language | English |
|---|---|
| Pages (from-to) | 70-71 |
| Number of pages | 2 |
| Journal | Journal of the Chemical Society, Chemical Communications |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Jan 1989 |
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A Reversible Inhibitor of P-Lactamase I from Bacillus cereus. / Jones, Mark; Buckwell, Stephen C.; Page, Michael I.; Wrigglesworth, Roger.
In: Journal of the Chemical Society, Chemical Communications, No. 2, 01.1989, p. 70-71.Research output: Contribution to journal › Article
TY - JOUR
T1 - A Reversible Inhibitor of P-Lactamase I from Bacillus cereus
AU - Jones, Mark
AU - Buckwell, Stephen C.
AU - Page, Michael I.
AU - Wrigglesworth, Roger
PY - 1989/1
Y1 - 1989/1
N2 - α-Methyl (3S,5R,6R)benzylpenicilloate is a reversible competitive inhibitor of β-lactamase l from Bacillus cereus; the inhibition constant Ki is 6.38 × 10-4M and is independent of pH between pH 5 and 8 which is compatible with binding of the free base form of the thiazolidine residue to the enzyme.
AB - α-Methyl (3S,5R,6R)benzylpenicilloate is a reversible competitive inhibitor of β-lactamase l from Bacillus cereus; the inhibition constant Ki is 6.38 × 10-4M and is independent of pH between pH 5 and 8 which is compatible with binding of the free base form of the thiazolidine residue to the enzyme.
UR - http://www.scopus.com/inward/record.url?scp=0024576827&partnerID=8YFLogxK
U2 - 10.1039/C39890000070
DO - 10.1039/C39890000070
M3 - Article
SP - 70
EP - 71
JO - Chemical Communications
JF - Chemical Communications
SN - 1359-7345
IS - 2
ER -