A Reversible Inhibitor of P-Lactamase I from Bacillus cereus

Mark Jones; Stephen C. Buckwell; Michael I. Page; Roger Wrigglesworth

doi:10.1039/C39890000070

A Reversible Inhibitor of P-Lactamase I from Bacillus cereus

Mark Jones, Stephen C. Buckwell, Michael I. Page, Roger Wrigglesworth

School of Applied Sciences

Sandoz Institute for Medical Research

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

α-Methyl (3S,5R,6R)benzylpenicilloate is a reversible competitive inhibitor of β-lactamase l from Bacillus cereus; the inhibition constant K_i is 6.38 × 10^-4M and is independent of pH between pH 5 and 8 which is compatible with binding of the free base form of the thiazolidine residue to the enzyme.

Original language	English
Pages (from-to)	70-71
Number of pages	2
Journal	Journal of the Chemical Society, Chemical Communications
Issue number	2
DOIs	https://doi.org/10.1039/C39890000070
Publication status	Published - Jan 1989

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title = "A Reversible Inhibitor of P-Lactamase I from Bacillus cereus",

abstract = "α-Methyl (3S,5R,6R)benzylpenicilloate is a reversible competitive inhibitor of β-lactamase l from Bacillus cereus; the inhibition constant Ki is 6.38 × 10-4M and is independent of pH between pH 5 and 8 which is compatible with binding of the free base form of the thiazolidine residue to the enzyme.",

author = "Mark Jones and Buckwell, \{Stephen C.\} and Page, \{Michael I.\} and Roger Wrigglesworth",

year = "1989",

month = jan,

doi = "10.1039/C39890000070",

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journal = "Journal of the Chemical Society, Chemical Communications",

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AU - Jones, Mark

AU - Buckwell, Stephen C.

AU - Page, Michael I.

AU - Wrigglesworth, Roger

PY - 1989/1

Y1 - 1989/1

N2 - α-Methyl (3S,5R,6R)benzylpenicilloate is a reversible competitive inhibitor of β-lactamase l from Bacillus cereus; the inhibition constant Ki is 6.38 × 10-4M and is independent of pH between pH 5 and 8 which is compatible with binding of the free base form of the thiazolidine residue to the enzyme.

AB - α-Methyl (3S,5R,6R)benzylpenicilloate is a reversible competitive inhibitor of β-lactamase l from Bacillus cereus; the inhibition constant Ki is 6.38 × 10-4M and is independent of pH between pH 5 and 8 which is compatible with binding of the free base form of the thiazolidine residue to the enzyme.

UR - https://www.scopus.com/pages/publications/0024576827

U2 - 10.1039/C39890000070

DO - 10.1039/C39890000070

M3 - Article

AN - SCOPUS:0024576827

SN - 0022-4936

SP - 70

EP - 71

JO - Journal of the Chemical Society, Chemical Communications

JF - Journal of the Chemical Society, Chemical Communications

IS - 2

ER -

A Reversible Inhibitor of P-Lactamase I from Bacillus cereus

Abstract

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