A Single Mutation in Cytochrome P450 BM3 Induces the Conformational Rearrangement Seen upon Substrate Binding in the Wild-type Enzyme

Medicine & Life Sciences

• Heme 100%
• Cytochrome P-450 Enzyme System 88%
• Iron 53%
• Mutation 50%
• Enzymes 49%
• palmitoleic acid 39%
• Ligands 27%
• Camphor 5-Monooxygenase 24%
• Oxidoreductases 23%
• Catalysis 15%
• Mixed Function Oxygenases 14%
• Oxidation-Reduction 12%
• Catalytic Domain 11%
• Ligation 11%
• Glutamic Acid 11%
• Fatty Acids 11%
• Electrons 10%
• Proteins 9%
• Oxygen 9%
• Water 8%

Chemistry

• Cytochrome P450 96%
• Heme 83%
• Mutation 76%
• Spin State 28%
• Crystal Structure 19%
• Ligand 16%
• Reduction Potential 13%
• Displacement 10%
• Fatty Acid 10%
• Electron Transfer 8%
• Catalysis 8%
• Dioxygen 6%
• Reduction 5%
• Protein 5%