A study of the production of neutrons for Boron Neutron Capture Therapy using a proton accelerator

T. R. Edgecock, J. R J Bennett, S. Green, B. Phoenix, M. C. Scott

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

Boron Neutron Capture Therapy (BNCT) is a binary cancer therapy particularly well-suited to treating aggressive tumours that exhibit a high degree of infiltration of the surrounding healthy tissue. Such tumours, for example of the brain and lung, provide some of the most challenging problems in oncology. The first element of the therapy is boron-10 which is preferentially introduced into the cancerous cells using a carrier compound. Boron-10 has a very high capture crosssection with the other element of the therapy, thermal neutrons, resulting in the production of a lithium nucleus and an alpha particle which destroy the cell they are created in. However, a large flux of neutrons is required and until recently the only source used was a nuclear reactor. In Birmingham, studies of an existing BNCT facility using a 2.8 MeV proton beam and a solid lithium target have found a way to increase the beam power to a sufficient level to allow clinical trials, while maintaining the target solid. In this paper, we will introduce BNCT, describe the work in Birmingham and compare with other accelerator-driven BNCT projects around the World.

Original languageEnglish
Title of host publicationIPAC 2014: Proceedings of the 5th International Particle Accelerator Conference
PublisherJoint Accelerator Conferences Website (JACoW)
Pages2195-2197
Number of pages3
ISBN (Electronic)9783954501328
Publication statusPublished - 1 Jul 2014
Event5th International Particle Accelerator Conference - Dresden, Germany
Duration: 15 Jun 201420 Jun 2014
Conference number: 5
http://inspirehep.net/record/1122761?ln=en (Link to Conference Details)

Conference

Conference5th International Particle Accelerator Conference
Abbreviated titleIPAC'14
CountryGermany
CityDresden
Period15/06/1420/06/14
Internet address

Fingerprint

therapy
boron
accelerators
neutrons
protons
boron 10
tumors
lithium
nuclear reactors
infiltration
thermal neutrons
cells
proton beams
lungs
alpha particles
brain
cancer
nuclei

Cite this

Edgecock, T. R., Bennett, J. R. J., Green, S., Phoenix, B., & Scott, M. C. (2014). A study of the production of neutrons for Boron Neutron Capture Therapy using a proton accelerator. In IPAC 2014: Proceedings of the 5th International Particle Accelerator Conference (pp. 2195-2197). Joint Accelerator Conferences Website (JACoW).
Edgecock, T. R. ; Bennett, J. R J ; Green, S. ; Phoenix, B. ; Scott, M. C. / A study of the production of neutrons for Boron Neutron Capture Therapy using a proton accelerator. IPAC 2014: Proceedings of the 5th International Particle Accelerator Conference. Joint Accelerator Conferences Website (JACoW), 2014. pp. 2195-2197
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Edgecock, TR, Bennett, JRJ, Green, S, Phoenix, B & Scott, MC 2014, A study of the production of neutrons for Boron Neutron Capture Therapy using a proton accelerator. in IPAC 2014: Proceedings of the 5th International Particle Accelerator Conference. Joint Accelerator Conferences Website (JACoW), pp. 2195-2197, 5th International Particle Accelerator Conference, Dresden, Germany, 15/06/14.

A study of the production of neutrons for Boron Neutron Capture Therapy using a proton accelerator. / Edgecock, T. R.; Bennett, J. R J; Green, S.; Phoenix, B.; Scott, M. C.

IPAC 2014: Proceedings of the 5th International Particle Accelerator Conference. Joint Accelerator Conferences Website (JACoW), 2014. p. 2195-2197.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

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N2 - Boron Neutron Capture Therapy (BNCT) is a binary cancer therapy particularly well-suited to treating aggressive tumours that exhibit a high degree of infiltration of the surrounding healthy tissue. Such tumours, for example of the brain and lung, provide some of the most challenging problems in oncology. The first element of the therapy is boron-10 which is preferentially introduced into the cancerous cells using a carrier compound. Boron-10 has a very high capture crosssection with the other element of the therapy, thermal neutrons, resulting in the production of a lithium nucleus and an alpha particle which destroy the cell they are created in. However, a large flux of neutrons is required and until recently the only source used was a nuclear reactor. In Birmingham, studies of an existing BNCT facility using a 2.8 MeV proton beam and a solid lithium target have found a way to increase the beam power to a sufficient level to allow clinical trials, while maintaining the target solid. In this paper, we will introduce BNCT, describe the work in Birmingham and compare with other accelerator-driven BNCT projects around the World.

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Edgecock TR, Bennett JRJ, Green S, Phoenix B, Scott MC. A study of the production of neutrons for Boron Neutron Capture Therapy using a proton accelerator. In IPAC 2014: Proceedings of the 5th International Particle Accelerator Conference. Joint Accelerator Conferences Website (JACoW). 2014. p. 2195-2197