A theoretical framework for the analysis of optical anisotropy in birefringent biological tissues with polarization-sensitive optical coherence tomography

Deepa K. Kasaragod, Zenghai Lu, James Jacobs, Stephen J. Matcher

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Polarization-sensitive optical coherence tomography (PSOCT) has established itself as an important non-invasive optical imaging tool to study the birefringent biological tissues. The complex 3D structure architecture of the collagen fibers in articular cartilage is investigated using a time domain PSOCT (TD-PSOCT) system and the depth-wise cumulative retardance profiles obtained are compared with a three layer cartilage model. The PSOCT result obtained from the variable incidence angle (VIA) experiment of bovine cartilage sample is found to be consistent with the proposed lamellar cartilage model based on scanning electron microscope studies. This shows potential use of PSOCT-VIA technique to obtain depth-wise information about the complex 3D architecture of collagen fibers in the cartilage. Further studies would have to be carried out to map out depth wise retardance information at different sites of the cartilage, which could establish the general validity of this approach.

Original languageEnglish
Title of host publicationEuropean Conference on Biomedical Optics, ECBO 2011
PublisherOptical Society of America
ISBN (Print)9780819486837
DOIs
Publication statusPublished - 22 May 2011
Externally publishedYes
EventEuropean Conference on Biomedical Optics - Munich, Germany
Duration: 22 May 201126 May 2011

Publication series

NameOptics InfoBase Conference Papers
ISSN (Electronic)2162-2701

Conference

ConferenceEuropean Conference on Biomedical Optics
Abbreviated titleECBO 2011
Country/TerritoryGermany
CityMunich
Period22/05/1126/05/11

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