A thiazine-S-oxide, Staudinger/aza-Wittig based synthesis of benzodiazepines and benzothiadiazepines

Balques Anwar, Paul Grimsey, Karl Hemming, Matthew Krajniewski, Christina Loukou

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

A new approach to the synthesis of imine containing 1,2,5-benzothiadiazepine-1,1-dioxides and 1,4-benzodiazepin-5-ones using iminophosphoranyl thiazine-S-oxides as precursors is reported. Key steps include a Staudinger reaction, an aza-Wittig reaction and the conversion of a thiazine-S-oxide into an amino ketone via a [2,3] sigmatropic rearrangement. (C) 2000 Elsevier Science Ltd.

LanguageEnglish
Pages10107-10110
Number of pages4
JournalTetrahedron Letters
Volume41
Issue number51
DOIs
Publication statusPublished - 16 Dec 2000
Externally publishedYes

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Thiazines
Benzodiazepines
Oxides
Conversion Disorder
Imines
Ketones

Cite this

Anwar, Balques ; Grimsey, Paul ; Hemming, Karl ; Krajniewski, Matthew ; Loukou, Christina. / A thiazine-S-oxide, Staudinger/aza-Wittig based synthesis of benzodiazepines and benzothiadiazepines. In: Tetrahedron Letters. 2000 ; Vol. 41, No. 51. pp. 10107-10110.
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A thiazine-S-oxide, Staudinger/aza-Wittig based synthesis of benzodiazepines and benzothiadiazepines. / Anwar, Balques; Grimsey, Paul; Hemming, Karl; Krajniewski, Matthew; Loukou, Christina.

In: Tetrahedron Letters, Vol. 41, No. 51, 16.12.2000, p. 10107-10110.

Research output: Contribution to journalArticle

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