A thiazine-S-oxide, Staudinger/aza-Wittig based synthesis of benzodiazepines and benzothiadiazepines

Balques Anwar, Paul Grimsey, Karl Hemming, Matthew Krajniewski, Christina Loukou

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

A new approach to the synthesis of imine containing 1,2,5-benzothiadiazepine-1,1-dioxides and 1,4-benzodiazepin-5-ones using iminophosphoranyl thiazine-S-oxides as precursors is reported. Key steps include a Staudinger reaction, an aza-Wittig reaction and the conversion of a thiazine-S-oxide into an amino ketone via a [2,3] sigmatropic rearrangement. (C) 2000 Elsevier Science Ltd.

Original languageEnglish
Pages (from-to)10107-10110
Number of pages4
JournalTetrahedron Letters
Volume41
Issue number51
DOIs
Publication statusPublished - 16 Dec 2000
Externally publishedYes

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