Accelerator-driven boron neutron capture therapy

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Boron Neutron Capture Therapy is a binary treatment for certain types of cancer. It works by loading the cancerous cells with a boron-10 carrying compound. This isotope has a large cross-section for thermal neutrons, the reaction producing a lithium nucleus and alpha particle that kill the cell in which they are produced. Recent studies of the boron carrier compound indicate that the uptake process works best in particularly aggressive cancers. Most studied is glioblastoma multiforme and a trial using a combination of BNCT and X-ray radiotherapy has shown an increase of nearly a factor of two in mean survival over the state of the art. However, the main technical problem with BNCT remains producing a sufficient flux of neutrons for a reasonable treatment duration in a hospital environment. This paper discusses this issue.

LanguageEnglish
Article number1441004
JournalInternational Journal of Modern Physics A
Volume29
Issue number14
DOIs
Publication statusPublished - 10 Jun 2014

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therapy
boron
accelerators
boron 10
cancer
neutrons
thermal neutrons
cells
alpha particles
radiation therapy
isotopes
lithium
nuclei
cross sections
x rays

Cite this

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Accelerator-driven boron neutron capture therapy. / Edgecock, Rob.

In: International Journal of Modern Physics A, Vol. 29, No. 14, 1441004, 10.06.2014.

Research output: Contribution to journalArticle

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