Acute naltrexone does not remediate fronto-striatal disturbances in alcoholic and alcoholic polysubstance-dependent populations during a monetary incentive delay task

Liam J. Nestor, Anna Murphy, John McGonigle, Csaba Orban, Laurence Reed, Eleanor Taylor, Remy Flechais, Louise Paterson, Dana Smith, Edward T. Bullmore, Karen D. Ersche, John Suckling, Roger Tait, Rebecca Elliott, Bill Deakin, Ilan Rabiner, Anne Lingford-Hughes, David J. Nutt, Barbara Sahakian, T.W. Robbins & 1 others Trevor W. Robbins

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

There is a concerted research effort to investigate brain mechanisms underlying addiction processes that may predicate the development of new compounds for treating addiction. One target is the brain's opioid system, because of its role in the reinforcing effects of substances of abuse. Substance-dependent populations have increased numbers of the mu opioid receptor (MOR) in fronto-striatal regions that predict drug relapse, and demonstrate disturbances in these regions during the processing of non-drug rewards. Naltrexone is currently licensed for alcohol and opiate dependence, and may remediate such disturbances through the blockade of MORs in fronto-striatal reward circuitry. Therefore, we examined the potential acute modulating effects of naltrexone on the anticipation of, and instrumental responding for, non-drug rewards in long-term abstinent alcoholics, alcoholic poly substance-dependent individuals and controls using a monetary incentive delay (MID) task during a randomized double blind placebo controlled functional MRI study. We report that the alcoholic poly substance-dependent group exhibited slower and less accurate instrumental responding compared to alcoholics and controls that was less evident after acute naltrexone treatment. However, naltrexone treatment was unable to remediate disturbances within fronto-striatal regions during reward anticipation and ‘missed’ rewards in either substance-dependent group. While we have not been able to identify the underlying neural mechanisms for improvement observed with naltrexone in the alcoholic poly-substance dependent group, we can confirm that both substance-dependent groups exhibit substantial neural deficits during an MID task, despite being in long-term abstinence.
Original languageEnglish
Pages (from-to)1576-1589
Number of pages14
JournalAddiction Biology
Volume22
Issue number6
Early online date6 Sep 2016
DOIs
Publication statusPublished - Nov 2017
Externally publishedYes

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Corpus Striatum
Naltrexone
Reward
Motivation
Population
Alcoholics
Opioid-Related Disorders
mu Opioid Receptor
Brain
Opioid Analgesics
Alcoholism
Substance-Related Disorders
Placebos
Magnetic Resonance Imaging
Recurrence
Therapeutics
Research
Pharmaceutical Preparations

Cite this

Nestor, Liam J. ; Murphy, Anna ; McGonigle, John ; Orban, Csaba ; Reed, Laurence ; Taylor, Eleanor ; Flechais, Remy ; Paterson, Louise ; Smith, Dana ; Bullmore, Edward T. ; Ersche, Karen D. ; Suckling, John ; Tait, Roger ; Elliott, Rebecca ; Deakin, Bill ; Rabiner, Ilan ; Lingford-Hughes, Anne ; Nutt, David J. ; Sahakian, Barbara ; Robbins, T.W. ; Robbins, Trevor W. / Acute naltrexone does not remediate fronto-striatal disturbances in alcoholic and alcoholic polysubstance-dependent populations during a monetary incentive delay task. In: Addiction Biology. 2017 ; Vol. 22, No. 6. pp. 1576-1589.
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Nestor, LJ, Murphy, A, McGonigle, J, Orban, C, Reed, L, Taylor, E, Flechais, R, Paterson, L, Smith, D, Bullmore, ET, Ersche, KD, Suckling, J, Tait, R, Elliott, R, Deakin, B, Rabiner, I, Lingford-Hughes, A, Nutt, DJ, Sahakian, B, Robbins, TW & Robbins, TW 2017, 'Acute naltrexone does not remediate fronto-striatal disturbances in alcoholic and alcoholic polysubstance-dependent populations during a monetary incentive delay task', Addiction Biology, vol. 22, no. 6, pp. 1576-1589. https://doi.org/10.1111/adb.12444

Acute naltrexone does not remediate fronto-striatal disturbances in alcoholic and alcoholic polysubstance-dependent populations during a monetary incentive delay task. / Nestor, Liam J.; Murphy, Anna; McGonigle, John; Orban, Csaba; Reed, Laurence; Taylor, Eleanor; Flechais, Remy; Paterson, Louise; Smith, Dana; Bullmore, Edward T.; Ersche, Karen D.; Suckling, John; Tait, Roger; Elliott, Rebecca; Deakin, Bill; Rabiner, Ilan; Lingford-Hughes, Anne; Nutt, David J.; Sahakian, Barbara; Robbins, T.W.; Robbins, Trevor W.

In: Addiction Biology, Vol. 22, No. 6, 11.2017, p. 1576-1589.

Research output: Contribution to journalArticle

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AU - Orban, Csaba

AU - Reed, Laurence

AU - Taylor, Eleanor

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AU - Paterson, Louise

AU - Smith, Dana

AU - Bullmore, Edward T.

AU - Ersche, Karen D.

AU - Suckling, John

AU - Tait, Roger

AU - Elliott, Rebecca

AU - Deakin, Bill

AU - Rabiner, Ilan

AU - Lingford-Hughes, Anne

AU - Nutt, David J.

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