Addition of amino esters to thiiranium ion intermediates: A novel approach to the synthesis of new potential aminopeptidase inhibitors

Duncan M. Gill, Neil A. Pegg, Christopher M. Rayner

Research output: Contribution to journalArticle


The use of amino esters tor the selective nucleophilic trapping of thiiranium ion intermediates generated in situ from homochiral 2,3-epoxy sulfides, allows synthetic access to a new class of compounds, structurally related to α-thiolbestatin and other known potent aminopeptidase inhibitors.

Original languageEnglish
Pages (from-to)8327-8330
Number of pages4
JournalTetrahedron Letters
Issue number45
Publication statusPublished - 6 Nov 1995
Externally publishedYes


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