In June 2014, the African Union, Heads of States and Government adopted the Protocol on Amendments to the Protocol on the Statute of the African Court of Justice and Human Rights (known in short as the Malabo Protocol). If ratified, the Protocol would expand the jurisdiction of the proposed African Court of Justice and Human Rights to adjudicate matters of corporate criminal liability in Africa. This paper analyses the prospects of advancing corporate respect for human rights and access to judicial remedies by victims of corporate human rights abuse through the lens of Article 46 (C) of the Malabo Protocol. The departure point is that the adoption and ratification of the Protocol would be an important step in preventing or stopping human rights violations by corporate actors in Africa's extractive resource industry. This position is predicated on the inference that the expanded jurisdiction provided by the Malabo Protocol is consistent with the commitment of African countries to implement Pillar II of the United Nations Guiding Principles on Business and Human Rights (Guiding Principles) on respect for human rights by corporate entities. In addition, the Malabo Protocol's proposal to adjudicate corporate criminal liability is consistent with Pillar III of the Guiding Principles on the provision of remedies for human rights violations. Creating a regional approach to address corporate criminality is an important African solution to a pressing African problem.