The global demand for commercial and domestic refrigeration and air conditioning systems has dramatically increased; currently it takes around third of the total worldwide energy consumption. Mechanical vapour compression refrigeration systems use refrigerants with adverse environmental effects. Sorption refrigeration systems offer the potential for better alternative to the mechanical vapour compression systems, if their technology can be improved to overcome current limitations. Sorption refrigeration systems are driven using low grade energy, solar energy and waste heat, and can operate with environmentally friendly refrigerants and non-corrosive materials. This chapter presents a comprehensive review for adsorption cooling systems, including adsorption principles, refrigerants used, adsorbent materials, working pairs, various bed designs, operating conditions, development techniques and their applications.