Allosteric and electrostatic reprogramming of a ditopic ligand

C.J. Baylies; L.P. Harding; J.C. Jeffery; T. Riis-Johannessen; C.R. Rice

doi:10.1002/anie.200460424

Allosteric and electrostatic reprogramming of a ditopic ligand

C.J. Baylies, L.P. Harding, J.C. Jeffery, T. Riis-Johannessen, C.R. Rice

Research output: Contribution to journal › Article › peer-review

27 Citations (Scopus)

Abstract

A potentially tetradentate pyridyl–thiazole ligand chain and an additional “external” crown ether binding site connect the two halves of a new ditopic ligand. The pyridyl‐thiazole binding sites can be changed or “reprogrammed” by the addition of Ba2+: In the presence of Hg2+ and Na+ the ligand L1 forms a dinuclear double helicate ([Hg2(L1)2Na2]6+), whereas in the presence of Hg2+ and Ba2+ a mononuclear species is formed ([Hg(L1)Ba]4+).

Original language	English
Pages (from-to)	4515-4518
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	43
Issue number	34
DOIs	https://doi.org/10.1002/anie.200460424
Publication status	Published - 25 Aug 2004

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abstract = "A potentially tetradentate pyridyl–thiazole ligand chain and an additional “external” crown ether binding site connect the two halves of a new ditopic ligand. The pyridyl‐thiazole binding sites can be changed or “reprogrammed” by the addition of Ba2+: In the presence of Hg2+ and Na+ the ligand L1 forms a dinuclear double helicate ([Hg2(L1)2Na2]6+), whereas in the presence of Hg2+ and Ba2+ a mononuclear species is formed ([Hg(L1)Ba]4+).",

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AU - Harding, L.P.

AU - Jeffery, J.C.

AU - Riis-Johannessen, T.

AU - Rice, C.R.

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AB - A potentially tetradentate pyridyl–thiazole ligand chain and an additional “external” crown ether binding site connect the two halves of a new ditopic ligand. The pyridyl‐thiazole binding sites can be changed or “reprogrammed” by the addition of Ba2+: In the presence of Hg2+ and Na+ the ligand L1 forms a dinuclear double helicate ([Hg2(L1)2Na2]6+), whereas in the presence of Hg2+ and Ba2+ a mononuclear species is formed ([Hg(L1)Ba]4+).

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ER -

Allosteric and electrostatic reprogramming of a ditopic ligand

Abstract

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