Allosteric and electrostatic reprogramming of a ditopic ligand

C.J. Baylies, L.P. Harding, J.C. Jeffery, T. Riis-Johannessen, C.R. Rice

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A potentially tetradentate pyridyl–thiazole ligand chain and an additional “external” crown ether binding site connect the two halves of a new ditopic ligand. The pyridyl‐thiazole binding sites can be changed or “reprogrammed” by the addition of Ba2+: In the presence of Hg2+ and Na+ the ligand L1 forms a dinuclear double helicate ([Hg2(L1)2Na2]6+), whereas in the presence of Hg2+ and Ba2+ a mononuclear species is formed ([Hg(L1)Ba]4+).
Original languageEnglish
Pages (from-to)4515-4518
Number of pages4
JournalAngewandte Chemie - International Edition
Issue number34
Publication statusPublished - 25 Aug 2004


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