Alzheimer Disease is not associated with polymorphisms in the angiotensinogen and renin genes

Alison Taylor, Mario Ezquerra, Gurjog Bagri, Agustin Yip, Louisa Goumidi, Dominique Cottel, Douglas Easton, John Grimley Evans, John Xuereb, Nigel J. Cairns, Philippe Amouyel, Marie‐Christine Chartier‐Harlin, Carol Brayne, David C. Rubinsztein

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Hypertension has been implicated as a riskfactor for Alzheimer disease (AD) anddementia in epidemiological studies ofhumans. It is thus possible that there arecommon genetic determinants for hyperten-sion and AD. Epidemiological, clinical, andexperimental data suggest that the renin-angiotensin-aldosterone system is a criticalregulator of blood pressure. The presence ofanMboI site in an RFLP in the renin geneand the Thr at the Met/Thr polymorphism atcodon 235 (M235T) of the angiotensinogengene have been reported to be associatedwith hypertension. These variants werestudied in autopsy-conÆrmed AD cases andmatched controls from the U.K. While noassociation was detected with the reninpolymorphism, a weak deleterious effectwas observed in cases homozygous for theangiotensinogen Thr allele. However, thisassociation was not observed in a Frenchcohort of clinically diagnosed AD cases andcontrols, suggesting that the initial observa-tion was a type I error. Thus, these poly-morphisms are unlikely to be associatedwith AD risk.
Original languageEnglish
Pages (from-to)761-764
Number of pages4
JournalAmerican Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
Volume105
Issue number8
Early online date7 Nov 2001
DOIs
Publication statusPublished - 8 Dec 2001
Externally publishedYes

Fingerprint

Angiotensinogen
Renin
Alzheimer Disease
Genes
Hypertension
Renin-Angiotensin System
Restriction Fragment Length Polymorphisms
Epidemiologic Studies
Autopsy
Alleles
Blood Pressure

Cite this

Taylor, Alison ; Ezquerra, Mario ; Bagri, Gurjog ; Yip, Agustin ; Goumidi, Louisa ; Cottel, Dominique ; Easton, Douglas ; Grimley Evans, John ; Xuereb, John ; J. Cairns, Nigel ; Amouyel, Philippe ; Chartier‐Harlin, Marie‐Christine ; Brayne, Carol ; C. Rubinsztein, David . / Alzheimer Disease is not associated with polymorphisms in the angiotensinogen and renin genes. In: American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics. 2001 ; Vol. 105, No. 8. pp. 761-764.
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title = "Alzheimer Disease is not associated with polymorphisms in the angiotensinogen and renin genes",
abstract = "Hypertension has been implicated as a riskfactor for Alzheimer disease (AD) anddementia in epidemiological studies ofhumans. It is thus possible that there arecommon genetic determinants for hyperten-sion and AD. Epidemiological, clinical, andexperimental data suggest that the renin-angiotensin-aldosterone system is a criticalregulator of blood pressure. The presence ofanMboI site in an RFLP in the renin geneand the Thr at the Met/Thr polymorphism atcodon 235 (M235T) of the angiotensinogengene have been reported to be associatedwith hypertension. These variants werestudied in autopsy-con{\AE}rmed AD cases andmatched controls from the U.K. While noassociation was detected with the reninpolymorphism, a weak deleterious effectwas observed in cases homozygous for theangiotensinogen Thr allele. However, thisassociation was not observed in a Frenchcohort of clinically diagnosed AD cases andcontrols, suggesting that the initial observa-tion was a type I error. Thus, these poly-morphisms are unlikely to be associatedwith AD risk.",
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author = "Alison Taylor and Mario Ezquerra and Gurjog Bagri and Agustin Yip and Louisa Goumidi and Dominique Cottel and Douglas Easton and {Grimley Evans}, John and John Xuereb and {J. Cairns}, Nigel and Philippe Amouyel and Marie‐Christine Chartier‐Harlin and Carol Brayne and {C. Rubinsztein}, David",
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Taylor, A, Ezquerra, M, Bagri, G, Yip, A, Goumidi, L, Cottel, D, Easton, D, Grimley Evans, J, Xuereb, J, J. Cairns, N, Amouyel, P, Chartier‐Harlin, MC, Brayne, C & C. Rubinsztein, D 2001, 'Alzheimer Disease is not associated with polymorphisms in the angiotensinogen and renin genes', American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics, vol. 105, no. 8, pp. 761-764. https://doi.org/10.1002/ajmg.10044

Alzheimer Disease is not associated with polymorphisms in the angiotensinogen and renin genes. / Taylor, Alison ; Ezquerra, Mario ; Bagri, Gurjog; Yip, Agustin ; Goumidi, Louisa ; Cottel, Dominique ; Easton, Douglas ; Grimley Evans, John ; Xuereb, John ; J. Cairns, Nigel; Amouyel, Philippe ; Chartier‐Harlin, Marie‐Christine ; Brayne, Carol ; C. Rubinsztein, David .

In: American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics, Vol. 105, No. 8, 08.12.2001, p. 761-764.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Alzheimer Disease is not associated with polymorphisms in the angiotensinogen and renin genes

AU - Taylor, Alison

AU - Ezquerra, Mario

AU - Bagri, Gurjog

AU - Yip, Agustin

AU - Goumidi, Louisa

AU - Cottel, Dominique

AU - Easton, Douglas

AU - Grimley Evans, John

AU - Xuereb, John

AU - J. Cairns, Nigel

AU - Amouyel, Philippe

AU - Chartier‐Harlin, Marie‐Christine

AU - Brayne, Carol

AU - C. Rubinsztein, David

PY - 2001/12/8

Y1 - 2001/12/8

N2 - Hypertension has been implicated as a riskfactor for Alzheimer disease (AD) anddementia in epidemiological studies ofhumans. It is thus possible that there arecommon genetic determinants for hyperten-sion and AD. Epidemiological, clinical, andexperimental data suggest that the renin-angiotensin-aldosterone system is a criticalregulator of blood pressure. The presence ofanMboI site in an RFLP in the renin geneand the Thr at the Met/Thr polymorphism atcodon 235 (M235T) of the angiotensinogengene have been reported to be associatedwith hypertension. These variants werestudied in autopsy-conÆrmed AD cases andmatched controls from the U.K. While noassociation was detected with the reninpolymorphism, a weak deleterious effectwas observed in cases homozygous for theangiotensinogen Thr allele. However, thisassociation was not observed in a Frenchcohort of clinically diagnosed AD cases andcontrols, suggesting that the initial observa-tion was a type I error. Thus, these poly-morphisms are unlikely to be associatedwith AD risk.

AB - Hypertension has been implicated as a riskfactor for Alzheimer disease (AD) anddementia in epidemiological studies ofhumans. It is thus possible that there arecommon genetic determinants for hyperten-sion and AD. Epidemiological, clinical, andexperimental data suggest that the renin-angiotensin-aldosterone system is a criticalregulator of blood pressure. The presence ofanMboI site in an RFLP in the renin geneand the Thr at the Met/Thr polymorphism atcodon 235 (M235T) of the angiotensinogengene have been reported to be associatedwith hypertension. These variants werestudied in autopsy-conÆrmed AD cases andmatched controls from the U.K. While noassociation was detected with the reninpolymorphism, a weak deleterious effectwas observed in cases homozygous for theangiotensinogen Thr allele. However, thisassociation was not observed in a Frenchcohort of clinically diagnosed AD cases andcontrols, suggesting that the initial observa-tion was a type I error. Thus, these poly-morphisms are unlikely to be associatedwith AD risk.

KW - Alzheimer disease

KW - dementia

KW - renin

KW - angiotensinogen

KW - MRC CFAS study

U2 - 10.1002/ajmg.10044

DO - 10.1002/ajmg.10044

M3 - Article

VL - 105

SP - 761

EP - 764

JO - American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics

JF - American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics

SN - 1552-4841

IS - 8

ER -