Alzheimer Disease is not associated with polymorphisms in the angiotensinogen and renin genes

Alison Taylor, Mario Ezquerra, Gurjog Bagri, Agustin Yip, Louisa Goumidi, Dominique Cottel, Douglas Easton, John Grimley Evans, John Xuereb, Nigel J. Cairns, Philippe Amouyel, Marie‐Christine Chartier‐Harlin, Carol Brayne, David C. Rubinsztein

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Hypertension has been implicated as a riskfactor for Alzheimer disease (AD) anddementia in epidemiological studies ofhumans. It is thus possible that there arecommon genetic determinants for hyperten-sion and AD. Epidemiological, clinical, andexperimental data suggest that the renin-angiotensin-aldosterone system is a criticalregulator of blood pressure. The presence ofanMboI site in an RFLP in the renin geneand the Thr at the Met/Thr polymorphism atcodon 235 (M235T) of the angiotensinogengene have been reported to be associatedwith hypertension. These variants werestudied in autopsy-conÆrmed AD cases andmatched controls from the U.K. While noassociation was detected with the reninpolymorphism, a weak deleterious effectwas observed in cases homozygous for theangiotensinogen Thr allele. However, thisassociation was not observed in a Frenchcohort of clinically diagnosed AD cases andcontrols, suggesting that the initial observa-tion was a type I error. Thus, these poly-morphisms are unlikely to be associatedwith AD risk.
Original languageEnglish
Pages (from-to)761-764
Number of pages4
JournalAmerican Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
Volume105
Issue number8
Early online date7 Nov 2001
DOIs
Publication statusPublished - 8 Dec 2001
Externally publishedYes

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