An Easy Synthetic Approach to Construct Some Ebselen Analogues and Benzo[b]selenophene Derivatives: Their Antioxidant and Cytotoxic Assessment

Mohamed Elsherbini, Wafaa S. Hamama, Hanafi H. Zoorob

Research output: Contribution to journalArticle

1 Citation (Scopus)


2-(Chloroseleno)benzoyl chloride serves as a versatile building block for the synthesis of novel ebselen (2-phenyl-1,2-benzisoselenazol-3(2H)-one) analogues and benzo[b]selenophen-3(2H)-one derivatives. The antioxidant activity and cytotoxic evaluation of the newly synthesized compounds were implemented. Among all the synthesized compounds, 1-(3-hydroxybenzo[b]selenophen-2-yl)ethanone oxime (9) was the most potent antioxidant and the most cytotoxic compound as well.

Original languageEnglish
Pages (from-to)1645-1650
Number of pages6
JournalJournal of Heterocyclic Chemistry
Issue number7
Early online date5 Jun 2018
Publication statusPublished - Jul 2018
Externally publishedYes


Cite this