An Easy Synthetic Approach to Construct Some Ebselen Analogues and Benzo[b]selenophene Derivatives

Their Antioxidant and Cytotoxic Assessment

Mohamed Elsherbini, Wafaa S. Hamama, Hanafi H. Zoorob

Research output: Contribution to journalArticle

Abstract

2-(Chloroseleno)benzoyl chloride serves as a versatile building block for the synthesis of novel ebselen (2-phenyl-1,2-benzisoselenazol-3(2H)-one) analogues and benzo[b]selenophen-3(2H)-one derivatives. The antioxidant activity and cytotoxic evaluation of the newly synthesized compounds were implemented. Among all the synthesized compounds, 1-(3-hydroxybenzo[b]selenophen-2-yl)ethanone oxime (9) was the most potent antioxidant and the most cytotoxic compound as well.

Original languageEnglish
Pages (from-to)1645-1650
Number of pages6
JournalJournal of Heterocyclic Chemistry
Volume55
Issue number7
Early online date5 Jun 2018
DOIs
Publication statusPublished - Jul 2018
Externally publishedYes

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Antioxidants
Derivatives
Oximes
ebselen
benzoyl chloride

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An Easy Synthetic Approach to Construct Some Ebselen Analogues and Benzo[b]selenophene Derivatives : Their Antioxidant and Cytotoxic Assessment. / Elsherbini, Mohamed; Hamama, Wafaa S.; Zoorob, Hanafi H.

In: Journal of Heterocyclic Chemistry, Vol. 55, No. 7, 07.2018, p. 1645-1650.

Research output: Contribution to journalArticle

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