An Easy Synthetic Approach to Construct Some Ebselen Analogues and Benzo[b]selenophene Derivatives: Their Antioxidant and Cytotoxic Assessment

Mohamed Elsherbini; Wafaa S. Hamama; Hanafi H. Zoorob

doi:10.1002/jhet.3199

An Easy Synthetic Approach to Construct Some Ebselen Analogues and Benzo[b]selenophene Derivatives: Their Antioxidant and Cytotoxic Assessment

Mohamed Elsherbini, Wafaa S. Hamama, Hanafi H. Zoorob

Research output: Contribution to journal › Article › peer-review

23 Citations (Scopus)

Abstract

2-(Chloroseleno)benzoyl chloride serves as a versatile building block for the synthesis of novel ebselen (2-phenyl-1,2-benzisoselenazol-3(2H)-one) analogues and benzo[b]selenophen-3(2H)-one derivatives. The antioxidant activity and cytotoxic evaluation of the newly synthesized compounds were implemented. Among all the synthesized compounds, 1-(3-hydroxybenzo[b]selenophen-2-yl)ethanone oxime (9) was the most potent antioxidant and the most cytotoxic compound as well.

Original language	English
Pages (from-to)	1645-1650
Number of pages	6
Journal	Journal of Heterocyclic Chemistry
Volume	55
Issue number	7
Early online date	5 Jun 2018
DOIs	https://doi.org/10.1002/jhet.3199
Publication status	Published - Jul 2018
Externally published	Yes

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SDG 3 Good Health and Well-being
SDG 9 Industry, Innovation, and Infrastructure

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abstract = "2-(Chloroseleno)benzoyl chloride serves as a versatile building block for the synthesis of novel ebselen (2-phenyl-1,2-benzisoselenazol-3(2H)-one) analogues and benzo[b]selenophen-3(2H)-one derivatives. The antioxidant activity and cytotoxic evaluation of the newly synthesized compounds were implemented. Among all the synthesized compounds, 1-(3-hydroxybenzo[b]selenophen-2-yl)ethanone oxime (9) was the most potent antioxidant and the most cytotoxic compound as well.",

author = "Mohamed Elsherbini and Hamama, \{Wafaa S.\} and Zoorob, \{Hanafi H.\}",

year = "2018",

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AU - Hamama, Wafaa S.

AU - Zoorob, Hanafi H.

PY - 2018/7

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N2 - 2-(Chloroseleno)benzoyl chloride serves as a versatile building block for the synthesis of novel ebselen (2-phenyl-1,2-benzisoselenazol-3(2H)-one) analogues and benzo[b]selenophen-3(2H)-one derivatives. The antioxidant activity and cytotoxic evaluation of the newly synthesized compounds were implemented. Among all the synthesized compounds, 1-(3-hydroxybenzo[b]selenophen-2-yl)ethanone oxime (9) was the most potent antioxidant and the most cytotoxic compound as well.

AB - 2-(Chloroseleno)benzoyl chloride serves as a versatile building block for the synthesis of novel ebselen (2-phenyl-1,2-benzisoselenazol-3(2H)-one) analogues and benzo[b]selenophen-3(2H)-one derivatives. The antioxidant activity and cytotoxic evaluation of the newly synthesized compounds were implemented. Among all the synthesized compounds, 1-(3-hydroxybenzo[b]selenophen-2-yl)ethanone oxime (9) was the most potent antioxidant and the most cytotoxic compound as well.

UR - https://www.scopus.com/pages/publications/85049811333

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JF - Journal of Heterocyclic Chemistry

IS - 7

ER -

An Easy Synthetic Approach to Construct Some Ebselen Analogues and Benzo[b]selenophene Derivatives: Their Antioxidant and Cytotoxic Assessment

Abstract

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