An Efficient Method for the Isolation of Toxins from Pteridium aquilinum and Evaluation of Ptaquiloside against Cancer and Non-cancer Cells

Courtney Williams, Simon J. Allison, Roger M. Phillips, Peter A. Linley, Colin W. Wright

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

The common fern, bracken (Pteridium aquilinum), is well known for its toxic effects on livestock due principally to the carcinogenic constituent ptaquiloside (1), although other toxins are present including the cyanogenic glycoside, prunasin (2). Here, we report an improved and relatively green process for the isolation of 1 and 2 from fresh bracken fronds and the evaluation of 1 for cytotoxicity against several cancer cell lines. The results indicate that 1 displays selective toxicity against cancer cells relative to noncancer retinal epithelial cells, and the improved method for the isolation of 1 is expected to facilitate further exploration of its pharmacological properties.

Original languageEnglish
Pages (from-to)892-895
Number of pages4
JournalPlanta Medica
Volume87
Issue number10-11
Early online date21 May 2021
DOIs
Publication statusPublished - 1 Aug 2021

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