An Efficient Method for the Isolation of Toxins from Pteridium aquilinum and Evaluation of Ptaquiloside against Cancer and Non-cancer Cells

Courtney Williams; Simon J. Allison; Roger M. Phillips; Peter A. Linley; Colin W. Wright

doi:10.1055/a-1494-3513

An Efficient Method for the Isolation of Toxins from Pteridium aquilinum and Evaluation of Ptaquiloside against Cancer and Non-cancer Cells

Courtney Williams, Simon J. Allison, Roger M. Phillips, Peter A. Linley, Colin W. Wright

University of Bradford

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

The common fern, bracken (Pteridium aquilinum), is well known for its toxic effects on livestock due principally to the carcinogenic constituent ptaquiloside (1), although other toxins are present including the cyanogenic glycoside, prunasin (2). Here, we report an improved and relatively green process for the isolation of 1 and 2 from fresh bracken fronds and the evaluation of 1 for cytotoxicity against several cancer cell lines. The results indicate that 1 displays selective toxicity against cancer cells relative to noncancer retinal epithelial cells, and the improved method for the isolation of 1 is expected to facilitate further exploration of its pharmacological properties.

Original language	English
Pages (from-to)	892-895
Number of pages	4
Journal	Planta Medica
Volume	87
Issue number	10-11
Early online date	21 May 2021
DOIs	https://doi.org/10.1055/a-1494-3513
Publication status	Published - 1 Aug 2021

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SDG 3 Good Health and Well-being

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title = "An Efficient Method for the Isolation of Toxins from Pteridium aquilinum and Evaluation of Ptaquiloside against Cancer and Non-cancer Cells",

abstract = "The common fern, bracken (Pteridium aquilinum), is well known for its toxic effects on livestock due principally to the carcinogenic constituent ptaquiloside (1), although other toxins are present including the cyanogenic glycoside, prunasin (2). Here, we report an improved and relatively green process for the isolation of 1 and 2 from fresh bracken fronds and the evaluation of 1 for cytotoxicity against several cancer cell lines. The results indicate that 1 displays selective toxicity against cancer cells relative to noncancer retinal epithelial cells, and the improved method for the isolation of 1 is expected to facilitate further exploration of its pharmacological properties.",

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T1 - An Efficient Method for the Isolation of Toxins from Pteridium aquilinum and Evaluation of Ptaquiloside against Cancer and Non-cancer Cells

AU - Williams, Courtney

AU - Allison, Simon J.

AU - Phillips, Roger M.

AU - Linley, Peter A.

AU - Wright, Colin W.

PY - 2021/8/1

Y1 - 2021/8/1

N2 - The common fern, bracken (Pteridium aquilinum), is well known for its toxic effects on livestock due principally to the carcinogenic constituent ptaquiloside (1), although other toxins are present including the cyanogenic glycoside, prunasin (2). Here, we report an improved and relatively green process for the isolation of 1 and 2 from fresh bracken fronds and the evaluation of 1 for cytotoxicity against several cancer cell lines. The results indicate that 1 displays selective toxicity against cancer cells relative to noncancer retinal epithelial cells, and the improved method for the isolation of 1 is expected to facilitate further exploration of its pharmacological properties.

AB - The common fern, bracken (Pteridium aquilinum), is well known for its toxic effects on livestock due principally to the carcinogenic constituent ptaquiloside (1), although other toxins are present including the cyanogenic glycoside, prunasin (2). Here, we report an improved and relatively green process for the isolation of 1 and 2 from fresh bracken fronds and the evaluation of 1 for cytotoxicity against several cancer cell lines. The results indicate that 1 displays selective toxicity against cancer cells relative to noncancer retinal epithelial cells, and the improved method for the isolation of 1 is expected to facilitate further exploration of its pharmacological properties.

KW - cytotoxic

KW - glycosidase

KW - prunasin

KW - ptaquiloside

KW - Pteridium aquilinum

UR - https://www.scopus.com/pages/publications/85106989756

U2 - 10.1055/a-1494-3513

DO - 10.1055/a-1494-3513

M3 - Article

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AN - SCOPUS:85106989756

SN - 0032-0943

VL - 87

SP - 892

EP - 895

JO - Planta Medica

JF - Planta Medica

IS - 10-11

ER -

An Efficient Method for the Isolation of Toxins from Pteridium aquilinum and Evaluation of Ptaquiloside against Cancer and Non-cancer Cells

Abstract

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