Abstract
The effects of γ-radiation sterilization on the parenteral excipient L-histidine were analysed by means of EPR spectroscopy. The irradiation process was found to induce the formation of a deamination radical which was persistent in the solid state. The nature and reactivity of the radicals following dissolution in water was evaluated using spin-trapping EPR experiments. The deamination radical was found to regenerate in solution in the presence of trace metals, potentially leading to radical induced degradation reactions occurring up to an hour after the dissolution process. Understanding this process is significant for the improved design of parental pharmaceutical formulations in which unwanted radical reactions after γ‐radiation sterilization could lead to degradation of active ingredients.
Original language | English |
---|---|
Pages (from-to) | 315-319 |
Number of pages | 5 |
Journal | International Journal of Pharmaceutics |
Volume | 533 |
Issue number | 1 |
Early online date | 28 Sep 2017 |
DOIs | |
Publication status | Published - 25 Nov 2017 |
Externally published | Yes |
Fingerprint
Dive into the research topics of 'An Electron Paramagnetic Resonance (EPR) spectroscopy study on the γ irradiation sterilization of the pharmaceutical excipient L histidine: regeneration of the radicals in solution'. Together they form a unique fingerprint.Profiles
-
Christopher Wedge
- School of Applied Sciences
- Centre for Functional Materials - Member
- Pharmaceutics and Drug Delivery Centre - Associate Member
- Structural, Molecular and Dynamic Modelling Centre - Associate Member
Person