An Improved Method for Difluorocyclopropanation of Alkenes

Duncan Gill, Neil Mclay, Michael Waring, Christopher Wilkinson, Joseph Sweeney

Research output: Contribution to journalLetterpeer-review

13 Citations (Scopus)


ifluorocyclopropanation of alkenes using fluorinated acetate salts using convential heating is often a slow, inefficient, and energy-intensive process. We report here a modified protocol which enables the rapid (<5 min) preparation of 1,1-difluorocyclopropanes, using microwave irradiation. The new procedure is not only considerably faster than previously reported methods, but it also employs easily removed, low boiling-point solvents and avoids the use of highly toxic or ozone-depleting substances. © Georg Thieme Verlag Stuttgart. New York.
Original languageEnglish
Pages (from-to)1756-1758
Number of pages3
Issue number12
Early online date26 Jun 2014
Publication statusPublished - 1 Jul 2014


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