An Improved Method for Difluorocyclopropanation of Alkenes

Duncan Gill, Neil Mclay, Michael Waring, Christopher Wilkinson, Joseph Sweeney

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

ifluorocyclopropanation of alkenes using fluorinated acetate salts using convential heating is often a slow, inefficient, and energy-intensive process. We report here a modified protocol which enables the rapid (<5 min) preparation of 1,1-difluorocyclopropanes, using microwave irradiation. The new procedure is not only considerably faster than previously reported methods, but it also employs easily removed, low boiling-point solvents and avoids the use of highly toxic or ozone-depleting substances. © Georg Thieme Verlag Stuttgart. New York.
LanguageEnglish
Pages1756-1758
Number of pages3
JournalSynlett
Volume25
Issue number12
Early online date26 Jun 2014
DOIs
Publication statusPublished - Jul 2014

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Microwave irradiation
Poisons
Ozone
Boiling point
Alkenes
Acetates
Salts
Heating

Cite this

Gill, D., Mclay, N., Waring, M., Wilkinson, C., & Sweeney, J. (2014). An Improved Method for Difluorocyclopropanation of Alkenes. Synlett, 25(12), 1756-1758. https://doi.org/10.1055/s-004-27354
Gill, Duncan ; Mclay, Neil ; Waring, Michael ; Wilkinson, Christopher ; Sweeney, Joseph. / An Improved Method for Difluorocyclopropanation of Alkenes. In: Synlett. 2014 ; Vol. 25, No. 12. pp. 1756-1758.
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Gill, D, Mclay, N, Waring, M, Wilkinson, C & Sweeney, J 2014, 'An Improved Method for Difluorocyclopropanation of Alkenes', Synlett, vol. 25, no. 12, pp. 1756-1758. https://doi.org/10.1055/s-004-27354

An Improved Method for Difluorocyclopropanation of Alkenes. / Gill, Duncan; Mclay, Neil; Waring, Michael; Wilkinson, Christopher; Sweeney, Joseph.

In: Synlett, Vol. 25, No. 12, 07.2014, p. 1756-1758.

Research output: Contribution to journalArticle

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Gill D, Mclay N, Waring M, Wilkinson C, Sweeney J. An Improved Method for Difluorocyclopropanation of Alkenes. Synlett. 2014 Jul;25(12):1756-1758. https://doi.org/10.1055/s-004-27354