An intramolecular, Pd-mediated α-arylation route to 4-aryl-2-naphthols

Stuart Aiken, Ben Armitage, Christopher D. Gabbutt, Bernard Heron

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)


1-Aryl-1-(2-bromophenyl)but-2-yn-1-ols, obtained from the addition of prop-1-yn-1-yllithium to 2-bromobenzophenones, readily rearrange to 4-aryl-4-(2-bromophenyl)but-3-en-2-ones upon treatment with TFA. Subsequent intramolecular Pd-mediated α-arylation of these but-3-en-2-ones gave 4-aryl-2-naphthols which were smoothly transformed into photochromic naphthopyrans. © 2015 Elsevier Ltd. All rights reserved.
Original languageEnglish
Pages (from-to)4840-4842
Number of pages3
JournalTetrahedron Letters
Issue number33
Early online date10 Jul 2015
Publication statusPublished - 12 Aug 2015


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