An updated review of folate-functionalized nanocarriers: a promising ligand in cancer

Pedram Ebrahimnejad; Arezoo Sodagar Taleghani; Kofi Asare-Addo; Ali Nokhodchi

doi:10.1016/j.drudis.2021.11.011

An updated review of folate-functionalized nanocarriers: a promising ligand in cancer

Pedram Ebrahimnejad, Arezoo Sodagar Taleghani, Kofi Asare-Addo, Ali Nokhodchi

Research output: Contribution to journal › Review article › peer-review

48 Citations (Scopus)

Abstract

The uncontrolled release of drugs in conventional drug delivery systems has led to the introduction of new nanotechnology-based drug delivery systems and the use of targeted nanocarriers for cancer treatment. These targeted nanocarriers, which consist of intelligent nanoparticles modified with targeting ligands, can deliver drugs to specified locations at the right time and reduce drug doses to prevent side effects. Folate is a suitable targeting ligand for folate receptors overexpressed on cancer cells and has shown promising results in the diagnosis and treatment of cancer. In this review, we highlight the latest developments on the use of folate-conjugated nanoparticles in cancer diagnosis and treatment. Moreover, the toxicity, biocompatibility and efficacy of these nanocarriers are discussed.

Original language	English
Pages (from-to)	471-489
Number of pages	19
Journal	Drug Discovery Today
Volume	27
Issue number	2
Early online date	13 Nov 2021
DOIs	https://doi.org/10.1016/j.drudis.2021.11.011
Publication status	Published - 1 Feb 2022

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.drudis.2021.11.011Licence: Unspecified

Kofi-for PURE Final Manuscript_Application of folic acidAccepted author manuscript, 952 KBLicence: CC BY-NC-ND

Cite this

@article{f083ae2fe68f4c6da794b603b5181e09,

title = "An updated review of folate-functionalized nanocarriers: a promising ligand in cancer",

abstract = "The uncontrolled release of drugs in conventional drug delivery systems has led to the introduction of new nanotechnology-based drug delivery systems and the use of targeted nanocarriers for cancer treatment. These targeted nanocarriers, which consist of intelligent nanoparticles modified with targeting ligands, can deliver drugs to specified locations at the right time and reduce drug doses to prevent side effects. Folate is a suitable targeting ligand for folate receptors overexpressed on cancer cells and has shown promising results in the diagnosis and treatment of cancer. In this review, we highlight the latest developments on the use of folate-conjugated nanoparticles in cancer diagnosis and treatment. Moreover, the toxicity, biocompatibility and efficacy of these nanocarriers are discussed.",

keywords = "Folic acid, Cancer therapy, Nanoparticles, Targeted delivery, Diagnosis",

author = "Pedram Ebrahimnejad and Taleghani, {Arezoo Sodagar} and Kofi Asare-Addo and Ali Nokhodchi",

year = "2022",

month = feb,

day = "1",

doi = "10.1016/j.drudis.2021.11.011",

language = "English",

volume = "27",

pages = "471--489",

journal = "Drug Discovery Today",

issn = "1359-6446",

publisher = "Elsevier Limited",

number = "2",

}

TY - JOUR

T1 - An updated review of folate-functionalized nanocarriers

T2 - a promising ligand in cancer

AU - Ebrahimnejad, Pedram

AU - Taleghani, Arezoo Sodagar

AU - Asare-Addo, Kofi

AU - Nokhodchi, Ali

PY - 2022/2/1

Y1 - 2022/2/1

N2 - The uncontrolled release of drugs in conventional drug delivery systems has led to the introduction of new nanotechnology-based drug delivery systems and the use of targeted nanocarriers for cancer treatment. These targeted nanocarriers, which consist of intelligent nanoparticles modified with targeting ligands, can deliver drugs to specified locations at the right time and reduce drug doses to prevent side effects. Folate is a suitable targeting ligand for folate receptors overexpressed on cancer cells and has shown promising results in the diagnosis and treatment of cancer. In this review, we highlight the latest developments on the use of folate-conjugated nanoparticles in cancer diagnosis and treatment. Moreover, the toxicity, biocompatibility and efficacy of these nanocarriers are discussed.

AB - The uncontrolled release of drugs in conventional drug delivery systems has led to the introduction of new nanotechnology-based drug delivery systems and the use of targeted nanocarriers for cancer treatment. These targeted nanocarriers, which consist of intelligent nanoparticles modified with targeting ligands, can deliver drugs to specified locations at the right time and reduce drug doses to prevent side effects. Folate is a suitable targeting ligand for folate receptors overexpressed on cancer cells and has shown promising results in the diagnosis and treatment of cancer. In this review, we highlight the latest developments on the use of folate-conjugated nanoparticles in cancer diagnosis and treatment. Moreover, the toxicity, biocompatibility and efficacy of these nanocarriers are discussed.

KW - Folic acid

KW - Cancer therapy

KW - Nanoparticles

KW - Targeted delivery

KW - Diagnosis

UR - http://www.scopus.com/inward/record.url?scp=85120312991&partnerID=8YFLogxK

U2 - 10.1016/j.drudis.2021.11.011

DO - 10.1016/j.drudis.2021.11.011

M3 - Review article

VL - 27

SP - 471

EP - 489

JO - Drug Discovery Today

JF - Drug Discovery Today

SN - 1359-6446

IS - 2

ER -

An updated review of folate-functionalized nanocarriers: a promising ligand in cancer

Abstract

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this