An updated review of folate-functionalized nanocarriers: a promising ligand in cancer

Pedram Ebrahimnejad; Arezoo Sodagar Taleghani; Kofi Asare-Addo; Ali Nokhodchi

doi:10.1016/j.drudis.2021.11.011

An updated review of folate-functionalized nanocarriers: a promising ligand in cancer

Pedram Ebrahimnejad, Arezoo Sodagar Taleghani, Kofi Asare-Addo, Ali Nokhodchi

Research output: Contribution to journal › Review article › peer-review

108 Citations (Scopus)

Abstract

The uncontrolled release of drugs in conventional drug delivery systems has led to the introduction of new nanotechnology-based drug delivery systems and the use of targeted nanocarriers for cancer treatment. These targeted nanocarriers, which consist of intelligent nanoparticles modified with targeting ligands, can deliver drugs to specified locations at the right time and reduce drug doses to prevent side effects. Folate is a suitable targeting ligand for folate receptors overexpressed on cancer cells and has shown promising results in the diagnosis and treatment of cancer. In this review, we highlight the latest developments on the use of folate-conjugated nanoparticles in cancer diagnosis and treatment. Moreover, the toxicity, biocompatibility and efficacy of these nanocarriers are discussed.

Original language	English
Pages (from-to)	471-489
Number of pages	19
Journal	Drug Discovery Today
Volume	27
Issue number	2
Early online date	13 Nov 2021
DOIs	https://doi.org/10.1016/j.drudis.2021.11.011
Publication status	Published - 1 Feb 2022

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SDG 3 Good Health and Well-being

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10.1016/j.drudis.2021.11.011Licence: Unspecified

Kofi-for PURE Final Manuscript_Application of folic acidAccepted author manuscript, 952 KBLicence: CC BY-NC-ND

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AB - The uncontrolled release of drugs in conventional drug delivery systems has led to the introduction of new nanotechnology-based drug delivery systems and the use of targeted nanocarriers for cancer treatment. These targeted nanocarriers, which consist of intelligent nanoparticles modified with targeting ligands, can deliver drugs to specified locations at the right time and reduce drug doses to prevent side effects. Folate is a suitable targeting ligand for folate receptors overexpressed on cancer cells and has shown promising results in the diagnosis and treatment of cancer. In this review, we highlight the latest developments on the use of folate-conjugated nanoparticles in cancer diagnosis and treatment. Moreover, the toxicity, biocompatibility and efficacy of these nanocarriers are discussed.

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An updated review of folate-functionalized nanocarriers: a promising ligand in cancer

Abstract

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