Anti-inflammatory, antipyretic and antispasmodic: Properties of Chromolaena odorata

O. B. Taiwo; O. A. Olajide; O. O. Soyannwo; J. M. Makinde

doi:10.1076/phbi.38.5.367.5970

Anti-inflammatory, antipyretic and antispasmodic: Properties of Chromolaena odorata

O. B. Taiwo, O. A. Olajide, O. O. Soyannwo, J. M. Makinde

Research output: Contribution to journal › Article › peer-review

33 Citations (Scopus)

Abstract

A methanol extract of the leaves of Chromolaena odorata was evaluated for anti-inflammatory effects in the carrageenan-induced rat paw edema model as well as for antipyretic activity in mice. The effects of the extract on intestinal transit of charcoal meal and castor oil-induced diarrhoea were also investigated. The extract (50-200 mg/kg) inhibited paw edema in rats and produced significant (p < 0.05) reduction in rectal temperature of mice rendered hyperthermic by yeast suspension. Antimotility and antidiarrhoeal effects were produced by the extract in intact mice. This study establishes the out-inflammatory, antipyretic, and antispasmodic properties of C. odorata.

Original language	English
Pages (from-to)	367-370
Number of pages	4
Journal	Pharmaceutical Biology
Volume	38
Issue number	5
DOIs	https://doi.org/10.1076/phbi.38.5.367.5970
Publication status	Published - 1 Dec 2000
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1076/phbi.38.5.367.5970

Cite this

@article{a8ba355776754c69a0dc10503ea28aa7,

title = "Anti-inflammatory, antipyretic and antispasmodic: Properties of Chromolaena odorata",

abstract = "A methanol extract of the leaves of Chromolaena odorata was evaluated for anti-inflammatory effects in the carrageenan-induced rat paw edema model as well as for antipyretic activity in mice. The effects of the extract on intestinal transit of charcoal meal and castor oil-induced diarrhoea were also investigated. The extract (50-200 mg/kg) inhibited paw edema in rats and produced significant (p < 0.05) reduction in rectal temperature of mice rendered hyperthermic by yeast suspension. Antimotility and antidiarrhoeal effects were produced by the extract in intact mice. This study establishes the out-inflammatory, antipyretic, and antispasmodic properties of C. odorata.",

keywords = "Anti-inflammatory, Antidiarrhoeal, Antipyretic, Antispasmodic, Chromolaena odorata (Linn.) King and Robinson",

author = "Taiwo, {O. B.} and Olajide, {O. A.} and Soyannwo, {O. O.} and Makinde, {J. M.}",

year = "2000",

month = dec,

day = "1",

doi = "10.1076/phbi.38.5.367.5970",

language = "English",

volume = "38",

pages = "367--370",

journal = "Pharmaceutical Biology",

issn = "1388-0209",

publisher = "Informa Healthcare",

number = "5",

}

TY - JOUR

T1 - Anti-inflammatory, antipyretic and antispasmodic

T2 - Properties of Chromolaena odorata

AU - Taiwo, O. B.

AU - Olajide, O. A.

AU - Soyannwo, O. O.

AU - Makinde, J. M.

PY - 2000/12/1

Y1 - 2000/12/1

N2 - A methanol extract of the leaves of Chromolaena odorata was evaluated for anti-inflammatory effects in the carrageenan-induced rat paw edema model as well as for antipyretic activity in mice. The effects of the extract on intestinal transit of charcoal meal and castor oil-induced diarrhoea were also investigated. The extract (50-200 mg/kg) inhibited paw edema in rats and produced significant (p < 0.05) reduction in rectal temperature of mice rendered hyperthermic by yeast suspension. Antimotility and antidiarrhoeal effects were produced by the extract in intact mice. This study establishes the out-inflammatory, antipyretic, and antispasmodic properties of C. odorata.

AB - A methanol extract of the leaves of Chromolaena odorata was evaluated for anti-inflammatory effects in the carrageenan-induced rat paw edema model as well as for antipyretic activity in mice. The effects of the extract on intestinal transit of charcoal meal and castor oil-induced diarrhoea were also investigated. The extract (50-200 mg/kg) inhibited paw edema in rats and produced significant (p < 0.05) reduction in rectal temperature of mice rendered hyperthermic by yeast suspension. Antimotility and antidiarrhoeal effects were produced by the extract in intact mice. This study establishes the out-inflammatory, antipyretic, and antispasmodic properties of C. odorata.

KW - Anti-inflammatory

KW - Antidiarrhoeal

KW - Antipyretic

KW - Antispasmodic

KW - Chromolaena odorata (Linn.) King and Robinson

UR - http://www.scopus.com/inward/record.url?scp=0034472355&partnerID=8YFLogxK

U2 - 10.1076/phbi.38.5.367.5970

DO - 10.1076/phbi.38.5.367.5970

M3 - Article

AN - SCOPUS:0034472355

VL - 38

SP - 367

EP - 370

JO - Pharmaceutical Biology

JF - Pharmaceutical Biology

SN - 1388-0209

IS - 5

ER -

Anti-inflammatory, antipyretic and antispasmodic: Properties of Chromolaena odorata

Abstract

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this