Anti-inflammatory, antipyretic and antispasmodic: Properties of Chromolaena odorata

O. B. Taiwo, O. A. Olajide, O. O. Soyannwo, J. M. Makinde

Research output: Contribution to journalArticlepeer-review

33 Citations (Scopus)


A methanol extract of the leaves of Chromolaena odorata was evaluated for anti-inflammatory effects in the carrageenan-induced rat paw edema model as well as for antipyretic activity in mice. The effects of the extract on intestinal transit of charcoal meal and castor oil-induced diarrhoea were also investigated. The extract (50-200 mg/kg) inhibited paw edema in rats and produced significant (p < 0.05) reduction in rectal temperature of mice rendered hyperthermic by yeast suspension. Antimotility and antidiarrhoeal effects were produced by the extract in intact mice. This study establishes the out-inflammatory, antipyretic, and antispasmodic properties of C. odorata.

Original languageEnglish
Pages (from-to)367-370
Number of pages4
JournalPharmaceutical Biology
Issue number5
Publication statusPublished - 1 Dec 2000
Externally publishedYes


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