Anti-inflammatory, antipyretic and antispasmodic

Properties of Chromolaena odorata

O. B. Taiwo, O. A. Olajide, O. O. Soyannwo, J. M. Makinde

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

A methanol extract of the leaves of Chromolaena odorata was evaluated for anti-inflammatory effects in the carrageenan-induced rat paw edema model as well as for antipyretic activity in mice. The effects of the extract on intestinal transit of charcoal meal and castor oil-induced diarrhoea were also investigated. The extract (50-200 mg/kg) inhibited paw edema in rats and produced significant (p < 0.05) reduction in rectal temperature of mice rendered hyperthermic by yeast suspension. Antimotility and antidiarrhoeal effects were produced by the extract in intact mice. This study establishes the out-inflammatory, antipyretic, and antispasmodic properties of C. odorata.

Original languageEnglish
Pages (from-to)367-370
Number of pages4
JournalPharmaceutical Biology
Volume38
Issue number5
DOIs
Publication statusPublished - 1 Dec 2000
Externally publishedYes

Fingerprint

Chromolaena
antipyretics
Chromolaena odorata
parasympatholytics
Parasympatholytics
Antipyretics
Rats
Anti-Inflammatory Agents
Castor Oil
Antidiarrheals
edema
Carrageenan
Charcoal
Edema
mice
extracts
antidiarrheal effect
Yeast
Methanol
castor oil

Cite this

Taiwo, O. B. ; Olajide, O. A. ; Soyannwo, O. O. ; Makinde, J. M. / Anti-inflammatory, antipyretic and antispasmodic : Properties of Chromolaena odorata. In: Pharmaceutical Biology. 2000 ; Vol. 38, No. 5. pp. 367-370.
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Anti-inflammatory, antipyretic and antispasmodic : Properties of Chromolaena odorata. / Taiwo, O. B.; Olajide, O. A.; Soyannwo, O. O.; Makinde, J. M.

In: Pharmaceutical Biology, Vol. 38, No. 5, 01.12.2000, p. 367-370.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Anti-inflammatory, antipyretic and antispasmodic

T2 - Properties of Chromolaena odorata

AU - Taiwo, O. B.

AU - Olajide, O. A.

AU - Soyannwo, O. O.

AU - Makinde, J. M.

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KW - Antispasmodic

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