Anti-inflammatory natural products

Olumayokun Olajide, Satyajit D. Sarker

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Chronic inflammation is now widely accepted to contribute to diseases such as asthma, cancer, cardiovascular diseases, inflammatory bowel diseases, metabolic syndrome, neurodegenerative diseases and rheumatic conditions. Most currently available anti-inflammatory drugs such as non-steroidal anti-inflammatory drugs (NSAIDs) and anti-inflammatory steroids have limitations associated with side effects and cost. Consequently, there is continued focus on plant-derived natural products to treat inflammatory disorders. This chapter explores the pharmacological actions of some naturally occurring, alkaloids, flavonoids and terpenes, which have shown promising benefits in both in vitro and in vivo experimental models reflecting the pathologies of inflammatory diseases. Due to their chemical diversity and known mechanisms of anti-inflammatory action, further clinical investigations on these natural products may result in the development of novel anti-inflammatory agents with minimal side effects. Natural products like the antimalarial artemisinin can be re-purposed as an anti-inflammatory drug.
Original languageEnglish
Title of host publicationMedicinal Natural Products
Subtitle of host publicationA Disease-Focused Approach
EditorsSatyajit Dey Sarker, Lutfun Nahar
PublisherAcademic Press Inc.
Chapter5
Pages153-177
Number of pages25
Volume55
Edition1st
ISBN (Print)9780128210192
DOIs
Publication statusE-pub ahead of print - 8 Apr 2020

Publication series

NameAnnual Reports in Medicinal Chemistry
PublisherAcademic Press Inc.
Volume55
ISSN (Print)0065-7743

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  • Cite this

    Olajide, O., & Sarker, S. D. (2020). Anti-inflammatory natural products. In S. D. Sarker, & L. Nahar (Eds.), Medicinal Natural Products: A Disease-Focused Approach (1st ed., Vol. 55, pp. 153-177). (Annual Reports in Medicinal Chemistry; Vol. 55). Academic Press Inc.. https://doi.org/10.1016/bs.armc.2020.02.002