Anti-inflammatory properties of Bridelia ferruginea stem bark: Inhibition of lipopolysaccaride-induced septic shock and vascular permeability

Olumayokun A. Olajide, David T. Okpako, Janet M. Makinde

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

The anti-inflammatory activity of the aqueous extract of Bridelia ferruginea stem bark was further evaluated in models which are mediated by tumour necrosis factor-alpha (TNFα). The effect of the extract on lipopolysaccharide (LPS)-induced septic shock was evaluated by measuring the number of deaths and the levels of serum alanine and aspartate aminotransferases following intraperitoneal injection of LPS (1μg/kg) into D-galactosamine-primed mice. LPS-induced vascular permeability on the back skin of mice was measured by the local accumulation of Evan's blue after subcutaneous injection of LPS. Pre-treatment with Bridelia ferruginea extract (10-80mg/kg) produced a dose-dependent inhibition of the septic shock syndrome in mice, with 80mg/kg of the extract exhibiting comparable activity as pentoxifylline (100mg/kg). LPS-induced dye leakage in the skin of mice was also suppressed by the extract (10-80mg/kg). Our study suggests that one of the mechanisms of the anti-inflammatory effects of Bridelia ferruginea possibly involve the suppression of TNFα up-regulation.

LanguageEnglish
Pages221-224
Number of pages4
JournalJournal of Ethnopharmacology
Volume88
Issue number2-3
DOIs
Publication statusPublished - 1 Oct 2003
Externally publishedYes

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Capillary Permeability
Septic Shock
Lipopolysaccharides
Anti-Inflammatory Agents
Pentoxifylline
Galactosamine
Evans Blue
Skin
Subcutaneous Injections
Aspartate Aminotransferases
Intraperitoneal Injections
Alanine Transaminase
Coloring Agents
Up-Regulation
Tumor Necrosis Factor-alpha
Serum

Cite this

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abstract = "The anti-inflammatory activity of the aqueous extract of Bridelia ferruginea stem bark was further evaluated in models which are mediated by tumour necrosis factor-alpha (TNFα). The effect of the extract on lipopolysaccharide (LPS)-induced septic shock was evaluated by measuring the number of deaths and the levels of serum alanine and aspartate aminotransferases following intraperitoneal injection of LPS (1μg/kg) into D-galactosamine-primed mice. LPS-induced vascular permeability on the back skin of mice was measured by the local accumulation of Evan's blue after subcutaneous injection of LPS. Pre-treatment with Bridelia ferruginea extract (10-80mg/kg) produced a dose-dependent inhibition of the septic shock syndrome in mice, with 80mg/kg of the extract exhibiting comparable activity as pentoxifylline (100mg/kg). LPS-induced dye leakage in the skin of mice was also suppressed by the extract (10-80mg/kg). Our study suggests that one of the mechanisms of the anti-inflammatory effects of Bridelia ferruginea possibly involve the suppression of TNFα up-regulation.",
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Anti-inflammatory properties of Bridelia ferruginea stem bark : Inhibition of lipopolysaccaride-induced septic shock and vascular permeability. / Olajide, Olumayokun A.; Okpako, David T.; Makinde, Janet M.

In: Journal of Ethnopharmacology, Vol. 88, No. 2-3, 01.10.2003, p. 221-224.

Research output: Contribution to journalArticle

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