Anti-inflammatory properties of cryptolepine

Olumayokun A. Olajide, Abayomi M. Ajayi, Colin W. Wright

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Cryptolepine is the major alkaloid of the West African shrub, Cryptolepis sanguinolenta. Cryptolepine has been shown to inhibit nitric oxide production, and DNA binding of Nuclear Factor-kappa B following inflammatory stimuli in vitro. In order to validate the anti-inflammatory property of this compound in vivo, we investigated its effects on a number of animal models of inflammation. Cryptolepine (10-40 mg/kg i.p.) produced significant dose-dependent inhibition of the carrageenan-induced rat paw oedema, and carrageenaninduced pleurisy in rats. These effects were compared with those of the non-steroidal anti-inflammatory drug indomethacin (10 mg/kg). At doses of 10-40 mg/kg i.p., cryptolepine inhibited lipopolysaccharide (LPS)-induced microvascular permeability in mice in a dose-related fashion. Oral administration of up to 40 mg/kg of the compound for four consecutive days did not induce gastric lesion formation in rats. Analgesic activity was also exhibited by cryptolepine through a dose-related (10-40 mg/kg i.p.) inhibition of writhing induced by i.p. administration of acetic acid in mice. The results of this study reveal that cryptolepine possesses in vivo anti-inflammatory activity.

LanguageEnglish
Pages1421-1425
Number of pages5
JournalPhytotherapy Research
Volume23
Issue number10
DOIs
Publication statusPublished - 28 Sep 2009
Externally publishedYes

Fingerprint

Anti-Inflammatory Agents
Cryptolepis
Pleurisy
NF-kappa B
Carrageenan
Capillary Permeability
Alkaloids
Indomethacin
Acetic Acid
Oral Administration
Analgesics
Lipopolysaccharides
cryptolepine
Edema
Stomach
Nitric Oxide
Animal Models
Inflammation
DNA
Pharmaceutical Preparations

Cite this

Olajide, Olumayokun A. ; Ajayi, Abayomi M. ; Wright, Colin W. / Anti-inflammatory properties of cryptolepine. In: Phytotherapy Research. 2009 ; Vol. 23, No. 10. pp. 1421-1425.
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Anti-inflammatory properties of cryptolepine. / Olajide, Olumayokun A.; Ajayi, Abayomi M.; Wright, Colin W.

In: Phytotherapy Research, Vol. 23, No. 10, 28.09.2009, p. 1421-1425.

Research output: Contribution to journalArticle

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