Antibacterial activity of cold atmospheric pressure argon plasma against 78 genetically different (mecA, luk-P, agr or Capsular Polysaccharide Type) staphylococcus aureus strains

Rutger Matthes; Anne Lührman; Silva Holtfreter; Julia Kolata; Dörte Radke; Nils Olaf Hübner; Ojan Assadian; Axel Kramer

doi:10.1159/000443210

Antibacterial activity of cold atmospheric pressure argon plasma against 78 genetically different (mecA, luk-P, agr or Capsular Polysaccharide Type) staphylococcus aureus strains

Rutger Matthes, Anne Lührman, Silva Holtfreter, Julia Kolata, Dörte Radke, Nils Olaf Hübner, Ojan Assadian, Axel Kramer

Department of Nursing

Research output: Contribution to journal › Article › peer-review

22 Citations (Scopus)

Abstract

Previous studies on the antimicrobial activity of cold atmospheric pressure argon plasma showed varying effects against mecA⁺ or mecA^-Staphylococcus aureus strains. This observation may have important clinical and epidemiological implications. Here, the antibacterial activity of argon plasma was investigated against 78 genetically different S. aureus strains, stratified by mecA, luk-P, agr1-4, or the cell wall capsule polysaccharide types 5 and 8. kINPen09® served as the plasma source for all experiments. On agar plates, mecA⁺luk-P^-S. aureus strains showed a decreased susceptibility against plasma compared to other S. aureus strains. This study underlines the high complexity of microbial defence against antimicrobial treatment and confirms a previously reported strain-dependent susceptibility of S. aureus to plasma treatment.

Original language	English
Pages (from-to)	83-91
Number of pages	9
Journal	Skin Pharmacology and Physiology
Volume	29
Issue number	2
DOIs	https://doi.org/10.1159/000443210
Publication status	Published - 1 May 2016

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Matthes, R., Lührman, A., Holtfreter, S., Kolata, J., Radke, D., Hübner, N. O., Assadian, O., & Kramer, A. (2016). Antibacterial activity of cold atmospheric pressure argon plasma against 78 genetically different (mecA, luk-P, agr or Capsular Polysaccharide Type) staphylococcus aureus strains. Skin Pharmacology and Physiology, 29(2), 83-91. https://doi.org/10.1159/000443210

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abstract = "Previous studies on the antimicrobial activity of cold atmospheric pressure argon plasma showed varying effects against mecA+ or mecA-Staphylococcus aureus strains. This observation may have important clinical and epidemiological implications. Here, the antibacterial activity of argon plasma was investigated against 78 genetically different S. aureus strains, stratified by mecA, luk-P, agr1-4, or the cell wall capsule polysaccharide types 5 and 8. kINPen09{\textregistered} served as the plasma source for all experiments. On agar plates, mecA+luk-P-S. aureus strains showed a decreased susceptibility against plasma compared to other S. aureus strains. This study underlines the high complexity of microbial defence against antimicrobial treatment and confirms a previously reported strain-dependent susceptibility of S. aureus to plasma treatment.",

keywords = "Antibacterial efficacy, Cold atmospheric pressure plasma, Methicillin-resistant S. aureus, Staphylococcus aureus, Tolerability, Virulence",

author = "Rutger Matthes and Anne L{\"u}hrman and Silva Holtfreter and Julia Kolata and D{\"o}rte Radke and H{\"u}bner, {Nils Olaf} and Ojan Assadian and Axel Kramer",

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Matthes, R, Lührman, A, Holtfreter, S, Kolata, J, Radke, D, Hübner, NO, Assadian, O & Kramer, A 2016, 'Antibacterial activity of cold atmospheric pressure argon plasma against 78 genetically different (mecA, luk-P, agr or Capsular Polysaccharide Type) staphylococcus aureus strains', Skin Pharmacology and Physiology, vol. 29, no. 2, pp. 83-91. https://doi.org/10.1159/000443210

Antibacterial activity of cold atmospheric pressure argon plasma against 78 genetically different (mecA, luk-P, agr or Capsular Polysaccharide Type) staphylococcus aureus strains. / Matthes, Rutger; Lührman, Anne; Holtfreter, Silva et al.

In: Skin Pharmacology and Physiology, Vol. 29, No. 2, 01.05.2016, p. 83-91.

Research output: Contribution to journal › Article › peer-review

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AU - Matthes, Rutger

AU - Lührman, Anne

AU - Holtfreter, Silva

AU - Kolata, Julia

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AU - Hübner, Nils Olaf

AU - Assadian, Ojan

AU - Kramer, Axel

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AB - Previous studies on the antimicrobial activity of cold atmospheric pressure argon plasma showed varying effects against mecA+ or mecA-Staphylococcus aureus strains. This observation may have important clinical and epidemiological implications. Here, the antibacterial activity of argon plasma was investigated against 78 genetically different S. aureus strains, stratified by mecA, luk-P, agr1-4, or the cell wall capsule polysaccharide types 5 and 8. kINPen09® served as the plasma source for all experiments. On agar plates, mecA+luk-P-S. aureus strains showed a decreased susceptibility against plasma compared to other S. aureus strains. This study underlines the high complexity of microbial defence against antimicrobial treatment and confirms a previously reported strain-dependent susceptibility of S. aureus to plasma treatment.

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Antibacterial activity of cold atmospheric pressure argon plasma against 78 genetically different (mecA, luk-P, agr or Capsular Polysaccharide Type) staphylococcus aureus strains

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