Antibodies to Voltage-Gated Calcium Channels in Children with Falciparum Malaria

Bethan Lang, Christopher I. Newbold, Graham Williams, Norbert Peshu, Kevin Marsh, Charles R J C Newton

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24 Citations (Scopus)

Abstract

Falciparum malaria can affect the central nervous system (CNS), causing neurological dysfunction and sequelae. The pathophysiology of these complications is currently very poorly understood. Production of autoantibodies has frequently been reported as a consequence of infection with Plasmodium falciparum. However, at present, the presence of antibodies to components of the CNS during malaria infection has not been reported. We have sought to identify such antibodies, define their specificity, and determine whether they are involved in the development of neurological complications of falciparum malaria. Here, we show that, in a cohort of Kenyan children, levels of antibodies to the voltage-gated calcium channels, but not to other ion channels, increased with the severity of malaria infection.

Original languageEnglish
Pages (from-to)117-121
Number of pages5
JournalJournal of Infectious Diseases
Volume191
Issue number1
Early online date1 Dec 2004
DOIs
Publication statusPublished - 1 Jan 2005
Externally publishedYes

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    Lang, B., Newbold, C. I., Williams, G., Peshu, N., Marsh, K., & Newton, C. R. J. C. (2005). Antibodies to Voltage-Gated Calcium Channels in Children with Falciparum Malaria. Journal of Infectious Diseases, 191(1), 117-121. https://doi.org/10.1086/426512