Antibodies to Voltage-Gated Calcium Channels in Children with Falciparum Malaria

Bethan Lang, Christopher I. Newbold, Graham Williams, Norbert Peshu, Kevin Marsh, Charles R J C Newton

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Falciparum malaria can affect the central nervous system (CNS), causing neurological dysfunction and sequelae. The pathophysiology of these complications is currently very poorly understood. Production of autoantibodies has frequently been reported as a consequence of infection with Plasmodium falciparum. However, at present, the presence of antibodies to components of the CNS during malaria infection has not been reported. We have sought to identify such antibodies, define their specificity, and determine whether they are involved in the development of neurological complications of falciparum malaria. Here, we show that, in a cohort of Kenyan children, levels of antibodies to the voltage-gated calcium channels, but not to other ion channels, increased with the severity of malaria infection.

Original languageEnglish
Pages (from-to)117-121
Number of pages5
JournalJournal of Infectious Diseases
Volume191
Issue number1
Early online date1 Dec 2004
DOIs
Publication statusPublished - 1 Jan 2005
Externally publishedYes

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Falciparum Malaria
Calcium Channels
Malaria
Antibodies
Central Nervous System
Infection
Plasmodium falciparum
Ion Channels
Autoantibodies

Cite this

Lang, B., Newbold, C. I., Williams, G., Peshu, N., Marsh, K., & Newton, C. R. J. C. (2005). Antibodies to Voltage-Gated Calcium Channels in Children with Falciparum Malaria. Journal of Infectious Diseases, 191(1), 117-121. https://doi.org/10.1086/426512
Lang, Bethan ; Newbold, Christopher I. ; Williams, Graham ; Peshu, Norbert ; Marsh, Kevin ; Newton, Charles R J C. / Antibodies to Voltage-Gated Calcium Channels in Children with Falciparum Malaria. In: Journal of Infectious Diseases. 2005 ; Vol. 191, No. 1. pp. 117-121.
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Lang, B, Newbold, CI, Williams, G, Peshu, N, Marsh, K & Newton, CRJC 2005, 'Antibodies to Voltage-Gated Calcium Channels in Children with Falciparum Malaria', Journal of Infectious Diseases, vol. 191, no. 1, pp. 117-121. https://doi.org/10.1086/426512

Antibodies to Voltage-Gated Calcium Channels in Children with Falciparum Malaria. / Lang, Bethan; Newbold, Christopher I.; Williams, Graham; Peshu, Norbert; Marsh, Kevin; Newton, Charles R J C.

In: Journal of Infectious Diseases, Vol. 191, No. 1, 01.01.2005, p. 117-121.

Research output: Contribution to journalArticle

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Lang B, Newbold CI, Williams G, Peshu N, Marsh K, Newton CRJC. Antibodies to Voltage-Gated Calcium Channels in Children with Falciparum Malaria. Journal of Infectious Diseases. 2005 Jan 1;191(1):117-121. https://doi.org/10.1086/426512