Anticancer, antifungal and antibacterial potential of bis(β-ketoiminato)ruthenium(II) carbonyl complexes

Cecilia R. Madzivire, Pablo Caramés-Méndez, Christopher M. Pask, Roger M. Phillips, Rianne M. Lord, Patrick C. McGowan

Research output: Contribution to journalArticle

Abstract

Herein we report a library of new ruthenium(II) complexes which incorporate a range of functionalised β-ketoiminate ligands. The complexes undergo an unusual reduction from Ru(III) to Ru(II), and consequently incorporate carbonyl ligands from the 2-ethoxyethanol solvent, forming ruthenium(II) dicarbonyl complexes. In order to address the potential applications of these complexes, we have screened the library against a range of tumour cell lines, however, all compounds exhibit low cellular activity and this is tentatively assigned to the decomposition of the compounds in aqueous media. Studies to establish the antifungal and antibacterial potential of these complexes was addressed and show increased growth inhibitions for C. neoformans and S. aureus species.

Original languageEnglish
Article number119025
JournalInorganica Chimica Acta
Volume498
Early online date9 Aug 2019
DOIs
Publication statusPublished - 1 Dec 2019

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Ruthenium
ruthenium
Ligands
ligands
cultured cells
Tumors
tumors
Cells
Decomposition
decomposition
2-ethoxyethanol

Cite this

Madzivire, Cecilia R. ; Caramés-Méndez, Pablo ; Pask, Christopher M. ; Phillips, Roger M. ; Lord, Rianne M. ; McGowan, Patrick C. / Anticancer, antifungal and antibacterial potential of bis(β-ketoiminato)ruthenium(II) carbonyl complexes. In: Inorganica Chimica Acta. 2019 ; Vol. 498.
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Anticancer, antifungal and antibacterial potential of bis(β-ketoiminato)ruthenium(II) carbonyl complexes. / Madzivire, Cecilia R.; Caramés-Méndez, Pablo; Pask, Christopher M.; Phillips, Roger M.; Lord, Rianne M.; McGowan, Patrick C.

In: Inorganica Chimica Acta, Vol. 498, 119025, 01.12.2019.

Research output: Contribution to journalArticle

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