TY - JOUR
T1 - Antimicrobial activity of five herbal extracts against Multi Drug Resistant (MDR) strains of bacteria and fungus of clinical origin
AU - Khan, Rosina
AU - Islam, Barira
AU - Akram, Mohd
AU - Shakil, Shazi
AU - Ahmad, Anis
AU - Ali, S. Manazir
AU - Siddiqui, Mashiatullah
AU - Khan, Asad U.
PY - 2009/2/4
Y1 - 2009/2/4
N2 - Antimicrobial activities of the crude ethanolic extracts of five plants were screened against multidrug resistant (MDR) strains of Escherichia coli, Klebsiella pneumoniae and Candida albicans. ATCC strains of Streptococcus mutans, Staphylococcus aureus, Enterococcus faecalis, Streptococcus bovis, Pseudimonas aeruginosa, Salmonella typhimurium, Escherichia coli, Klebsiella pneumoniae and Candida albicans were also tested. The strains that showed resistance against the maximum number of antibiotics tested were selected for an antibacterial assay. The MDR strains were sensitive to the antimicrobial activity of Acacia nilotica, Syzygium aromaticum and Cinnamum zeylanicum, whereas they exhibited strong resistance to the extracts of Terminalia arjuna and Eucalyptus globulus. Community-acquired infections showed higher sensitivity than the nosocomial infections against these extracts. The most potent antimicrobial plant was A. nilotica (MIC range 9.75-313μg/ml), whereas othercrude plant extracts studied in this report were found to exhibit higher MIC values than A. nilotica against community acquired as well as nosocomial infection. This study concludes that A. nilotica, C zeylanicum and S. aromaticum can be used against multidrug resistant microbes causing nosocomial and community acquired infections.
AB - Antimicrobial activities of the crude ethanolic extracts of five plants were screened against multidrug resistant (MDR) strains of Escherichia coli, Klebsiella pneumoniae and Candida albicans. ATCC strains of Streptococcus mutans, Staphylococcus aureus, Enterococcus faecalis, Streptococcus bovis, Pseudimonas aeruginosa, Salmonella typhimurium, Escherichia coli, Klebsiella pneumoniae and Candida albicans were also tested. The strains that showed resistance against the maximum number of antibiotics tested were selected for an antibacterial assay. The MDR strains were sensitive to the antimicrobial activity of Acacia nilotica, Syzygium aromaticum and Cinnamum zeylanicum, whereas they exhibited strong resistance to the extracts of Terminalia arjuna and Eucalyptus globulus. Community-acquired infections showed higher sensitivity than the nosocomial infections against these extracts. The most potent antimicrobial plant was A. nilotica (MIC range 9.75-313μg/ml), whereas othercrude plant extracts studied in this report were found to exhibit higher MIC values than A. nilotica against community acquired as well as nosocomial infection. This study concludes that A. nilotica, C zeylanicum and S. aromaticum can be used against multidrug resistant microbes causing nosocomial and community acquired infections.
KW - Antimicrobial agent
KW - Herbal extracts
KW - Multi-drug resistant
UR - http://www.scopus.com/inward/record.url?scp=61449203801&partnerID=8YFLogxK
U2 - 10.3390/molecules14020586
DO - 10.3390/molecules14020586
M3 - Article
C2 - 19214149
AN - SCOPUS:61449203801
VL - 14
SP - 586
EP - 597
JO - Molecules
JF - Molecules
SN - 1420-3049
IS - 2
ER -