Antimicrobial activity of five herbal extracts against Multi Drug Resistant (MDR) strains of bacteria and fungus of clinical origin

Rosina Khan, Barira Islam, Mohd Akram, Shazi Shakil, Anis Ahmad, S. Manazir Ali, Mashiatullah Siddiqui, Asad U. Khan

Research output: Contribution to journalArticle

161 Citations (Scopus)

Abstract

Antimicrobial activities of the crude ethanolic extracts of five plants were screened against multidrug resistant (MDR) strains of Escherichia coli, Klebsiella pneumoniae and Candida albicans. ATCC strains of Streptococcus mutans, Staphylococcus aureus, Enterococcus faecalis, Streptococcus bovis, Pseudimonas aeruginosa, Salmonella typhimurium, Escherichia coli, Klebsiella pneumoniae and Candida albicans were also tested. The strains that showed resistance against the maximum number of antibiotics tested were selected for an antibacterial assay. The MDR strains were sensitive to the antimicrobial activity of Acacia nilotica, Syzygium aromaticum and Cinnamum zeylanicum, whereas they exhibited strong resistance to the extracts of Terminalia arjuna and Eucalyptus globulus. Community-acquired infections showed higher sensitivity than the nosocomial infections against these extracts. The most potent antimicrobial plant was A. nilotica (MIC range 9.75-313μg/ml), whereas othercrude plant extracts studied in this report were found to exhibit higher MIC values than A. nilotica against community acquired as well as nosocomial infection. This study concludes that A. nilotica, C zeylanicum and S. aromaticum can be used against multidrug resistant microbes causing nosocomial and community acquired infections.

LanguageEnglish
Pages586-597
Number of pages12
JournalMolecules
Volume14
Issue number2
DOIs
Publication statusPublished - 4 Feb 2009
Externally publishedYes

Fingerprint

Community-Acquired Infections
fungi
Candida
infectious diseases
Fungi
Escherichia coli
bacteria
Syzygium
Bacteria
drugs
Klebsiella
Klebsiella pneumoniae
Cross Infection
streptococcus
pneumonia
Candida albicans
Salmonella
Plant Extracts
Escherichia
Complex Mixtures

Cite this

Khan, Rosina ; Islam, Barira ; Akram, Mohd ; Shakil, Shazi ; Ahmad, Anis ; Ali, S. Manazir ; Siddiqui, Mashiatullah ; Khan, Asad U. / Antimicrobial activity of five herbal extracts against Multi Drug Resistant (MDR) strains of bacteria and fungus of clinical origin. In: Molecules. 2009 ; Vol. 14, No. 2. pp. 586-597.
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Antimicrobial activity of five herbal extracts against Multi Drug Resistant (MDR) strains of bacteria and fungus of clinical origin. / Khan, Rosina; Islam, Barira; Akram, Mohd; Shakil, Shazi; Ahmad, Anis; Ali, S. Manazir; Siddiqui, Mashiatullah; Khan, Asad U.

In: Molecules, Vol. 14, No. 2, 04.02.2009, p. 586-597.

Research output: Contribution to journalArticle

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