Antiplatelet use in practice

Antiplatelets are widely used drugs that can prevent platelet activation and subsequent aggregation, inhibiting arterial thrombus formation that can contribute to the development of myocardial infarction and stroke. The use of antiplatelets for secondary prevention of cardiovascular disease is supported by a strong and compelling evidence base, with rigorous clinical trials supporting the use of varying combinations of antiplatelets for different indications. A sound understanding of how antiplatelets work is needed to promote their safe and effective use. This article briefly describes the process of platelet activation, aggregation and subsequent thrombus formation, and will discuss the mechanism of action of antiplatelets and their place in therapy.