Apolipoprotein E ε4 Allele Modulates the Immediate Impact of Acute Exercise on Prefrontal Function

Matteo De Marco, Peter Clough, Charlotte E. Dyer, Rebecca V. Vince, Jennifer S. Waby, Adrian W. Midgley, Annalena Venneri

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The difference between Apolipoprotein E ε4 carriers and non-carriers in response to single exercise sessions was tested. Stroop and Posner tasks were administered to young untrained women immediately after walking sessions or moderately heavy exercise. Exercise had a significantly more profound impact on the Stroop effect than on the Posner effect, suggesting selective involvement of prefrontal function. A significant genotype-by-exercise interaction indicated differences in response to exercise between ε4 carriers and non-carriers. Carriers showed facilitation triggered by exercise. The transient executive down-regulation was construed as due to exercise-dependent hypofrontality. The facilitation observed in carriers was interpreted as better management of prefrontal metabolic resources, and explained within the antagonistic pleiotropy hypothesis framework. The findings have implications for the interpretation of differences between ε4 carriers and non-carriers in the benefits triggered by long-term exercise that might depend, at least partially, on mechanisms of metabolic response to physical activity.
LanguageEnglish
Pages106-116
Number of pages11
JournalBehavior Genetics
Volume45
Issue number1
Early online date14 Sep 2014
DOIs
Publication statusPublished - Jan 2015
Externally publishedYes

Fingerprint

apolipoprotein E
facilitation
Apolipoproteins E
allele
exercise
Alleles
Exercise
pleiotropy
alleles
physical activity
walking
genotype
resource
Stroop Test
effect
Walking
Down-Regulation
Genotype
woman
regulation

Cite this

De Marco, Matteo ; Clough, Peter ; Dyer, Charlotte E. ; Vince, Rebecca V. ; Waby, Jennifer S. ; Midgley, Adrian W. ; Venneri, Annalena. / Apolipoprotein E ε4 Allele Modulates the Immediate Impact of Acute Exercise on Prefrontal Function. In: Behavior Genetics. 2015 ; Vol. 45, No. 1. pp. 106-116.
@article{9f879075d21044a58880432e1c56e5cf,
title = "Apolipoprotein E ε4 Allele Modulates the Immediate Impact of Acute Exercise on Prefrontal Function",
abstract = "The difference between Apolipoprotein E ε4 carriers and non-carriers in response to single exercise sessions was tested. Stroop and Posner tasks were administered to young untrained women immediately after walking sessions or moderately heavy exercise. Exercise had a significantly more profound impact on the Stroop effect than on the Posner effect, suggesting selective involvement of prefrontal function. A significant genotype-by-exercise interaction indicated differences in response to exercise between ε4 carriers and non-carriers. Carriers showed facilitation triggered by exercise. The transient executive down-regulation was construed as due to exercise-dependent hypofrontality. The facilitation observed in carriers was interpreted as better management of prefrontal metabolic resources, and explained within the antagonistic pleiotropy hypothesis framework. The findings have implications for the interpretation of differences between ε4 carriers and non-carriers in the benefits triggered by long-term exercise that might depend, at least partially, on mechanisms of metabolic response to physical activity.",
keywords = "Prefrontal cortex, Physiological response, Stroop test, Posner test, Alzheimer's disease",
author = "{De Marco}, Matteo and Peter Clough and Dyer, {Charlotte E.} and Vince, {Rebecca V.} and Waby, {Jennifer S.} and Midgley, {Adrian W.} and Annalena Venneri",
year = "2015",
month = "1",
doi = "10.1007/s10519-014-9675-5",
language = "English",
volume = "45",
pages = "106--116",
journal = "Behavior Genetics",
issn = "0001-8244",
publisher = "Springer New York",
number = "1",

}

Apolipoprotein E ε4 Allele Modulates the Immediate Impact of Acute Exercise on Prefrontal Function. / De Marco, Matteo; Clough, Peter; Dyer, Charlotte E.; Vince, Rebecca V.; Waby, Jennifer S.; Midgley, Adrian W.; Venneri, Annalena.

In: Behavior Genetics, Vol. 45, No. 1, 01.2015, p. 106-116.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Apolipoprotein E ε4 Allele Modulates the Immediate Impact of Acute Exercise on Prefrontal Function

AU - De Marco, Matteo

AU - Clough, Peter

AU - Dyer, Charlotte E.

AU - Vince, Rebecca V.

AU - Waby, Jennifer S.

AU - Midgley, Adrian W.

AU - Venneri, Annalena

PY - 2015/1

Y1 - 2015/1

N2 - The difference between Apolipoprotein E ε4 carriers and non-carriers in response to single exercise sessions was tested. Stroop and Posner tasks were administered to young untrained women immediately after walking sessions or moderately heavy exercise. Exercise had a significantly more profound impact on the Stroop effect than on the Posner effect, suggesting selective involvement of prefrontal function. A significant genotype-by-exercise interaction indicated differences in response to exercise between ε4 carriers and non-carriers. Carriers showed facilitation triggered by exercise. The transient executive down-regulation was construed as due to exercise-dependent hypofrontality. The facilitation observed in carriers was interpreted as better management of prefrontal metabolic resources, and explained within the antagonistic pleiotropy hypothesis framework. The findings have implications for the interpretation of differences between ε4 carriers and non-carriers in the benefits triggered by long-term exercise that might depend, at least partially, on mechanisms of metabolic response to physical activity.

AB - The difference between Apolipoprotein E ε4 carriers and non-carriers in response to single exercise sessions was tested. Stroop and Posner tasks were administered to young untrained women immediately after walking sessions or moderately heavy exercise. Exercise had a significantly more profound impact on the Stroop effect than on the Posner effect, suggesting selective involvement of prefrontal function. A significant genotype-by-exercise interaction indicated differences in response to exercise between ε4 carriers and non-carriers. Carriers showed facilitation triggered by exercise. The transient executive down-regulation was construed as due to exercise-dependent hypofrontality. The facilitation observed in carriers was interpreted as better management of prefrontal metabolic resources, and explained within the antagonistic pleiotropy hypothesis framework. The findings have implications for the interpretation of differences between ε4 carriers and non-carriers in the benefits triggered by long-term exercise that might depend, at least partially, on mechanisms of metabolic response to physical activity.

KW - Prefrontal cortex

KW - Physiological response

KW - Stroop test

KW - Posner test

KW - Alzheimer's disease

UR - https://link.springer.com/journal/10519

U2 - 10.1007/s10519-014-9675-5

DO - 10.1007/s10519-014-9675-5

M3 - Article

VL - 45

SP - 106

EP - 116

JO - Behavior Genetics

T2 - Behavior Genetics

JF - Behavior Genetics

SN - 0001-8244

IS - 1

ER -