Apparatus and method for testing medicaments

Hamid Merchant (Inventor), John Frost (Inventor), Abdul Basit (Inventor)

Research output: Patent

Abstract

Apparatus for testing the solubility of a medical dosage form includes a chamber (12) for holding a solvent medium (18), in the preferred embodiment a bicarbonate based buffer system. The apparatus also includes a pH probe (66) which is connectable to a supply of carbon dioxide (32, 34),as well as to a supply of helium (40), the supplies being controlled by a control unit (50). The control unit (50) monitors changes in pH of the solvent medium (18) and, as appropriate, feeds pH increasing and/or pH reducing gas from the supplies(32, 34, 40) into the chamber (12). The control unit (50) is able to maintain a uniform pH during testing or to provide a dynamically adjustable pH during testing, for example to three or more different pH levels in order to test the performance of a drug carrier at different levels of acidity or alkalinity for example, mimicking the conditions of the gastrointestinal tract. The apparatus(20) and associated method are particularly suitable for testing and developing dosage forms for oral delivery of drugs.
LanguageEnglish
Patent number2509286
IPCGB2509286
Priority date2/05/12
Publication statusPublished - 25 Jun 2014

Fingerprint

testing
methodology
drug carriers
helium
alkalinity
dosage
bicarbonates
gastrointestinal system
solubility
acidity
mouth
buffers
carbon dioxide
gases
drugs
monitoring

Cite this

Merchant, H., Frost, J., & Basit, A. (2014). IPC No. GB2509286. Apparatus and method for testing medicaments. (Patent No. 2509286).
Merchant, Hamid (Inventor) ; Frost, John (Inventor) ; Basit, Abdul (Inventor). / Apparatus and method for testing medicaments. IPC No.: GB2509286. Patent No.: 2509286.
@misc{c75f5be87f9a4bf5935679acf14d69dc,
title = "Apparatus and method for testing medicaments",
abstract = "Apparatus for testing the solubility of a medical dosage form includes a chamber (12) for holding a solvent medium (18), in the preferred embodiment a bicarbonate based buffer system. The apparatus also includes a pH probe (66) which is connectable to a supply of carbon dioxide (32, 34),as well as to a supply of helium (40), the supplies being controlled by a control unit (50). The control unit (50) monitors changes in pH of the solvent medium (18) and, as appropriate, feeds pH increasing and/or pH reducing gas from the supplies(32, 34, 40) into the chamber (12). The control unit (50) is able to maintain a uniform pH during testing or to provide a dynamically adjustable pH during testing, for example to three or more different pH levels in order to test the performance of a drug carrier at different levels of acidity or alkalinity for example, mimicking the conditions of the gastrointestinal tract. The apparatus(20) and associated method are particularly suitable for testing and developing dosage forms for oral delivery of drugs.",
keywords = "bicarboante buffer, drug release, Dissolution testing, Invitro invivo correlation",
author = "Hamid Merchant and John Frost and Abdul Basit",
year = "2014",
month = "6",
day = "25",
language = "English",
type = "Patent",
note = "2509286; GB2509286",

}

Merchant, H, Frost, J & Basit, A 2014, Apparatus and method for testing medicaments, Patent No. 2509286, IPC No. GB2509286.

Apparatus and method for testing medicaments. / Merchant, Hamid (Inventor); Frost, John (Inventor); Basit, Abdul (Inventor).

IPC No.: GB2509286. Patent No.: 2509286.

Research output: Patent

TY - PAT

T1 - Apparatus and method for testing medicaments

AU - Merchant, Hamid

AU - Frost, John

AU - Basit, Abdul

PY - 2014/6/25

Y1 - 2014/6/25

N2 - Apparatus for testing the solubility of a medical dosage form includes a chamber (12) for holding a solvent medium (18), in the preferred embodiment a bicarbonate based buffer system. The apparatus also includes a pH probe (66) which is connectable to a supply of carbon dioxide (32, 34),as well as to a supply of helium (40), the supplies being controlled by a control unit (50). The control unit (50) monitors changes in pH of the solvent medium (18) and, as appropriate, feeds pH increasing and/or pH reducing gas from the supplies(32, 34, 40) into the chamber (12). The control unit (50) is able to maintain a uniform pH during testing or to provide a dynamically adjustable pH during testing, for example to three or more different pH levels in order to test the performance of a drug carrier at different levels of acidity or alkalinity for example, mimicking the conditions of the gastrointestinal tract. The apparatus(20) and associated method are particularly suitable for testing and developing dosage forms for oral delivery of drugs.

AB - Apparatus for testing the solubility of a medical dosage form includes a chamber (12) for holding a solvent medium (18), in the preferred embodiment a bicarbonate based buffer system. The apparatus also includes a pH probe (66) which is connectable to a supply of carbon dioxide (32, 34),as well as to a supply of helium (40), the supplies being controlled by a control unit (50). The control unit (50) monitors changes in pH of the solvent medium (18) and, as appropriate, feeds pH increasing and/or pH reducing gas from the supplies(32, 34, 40) into the chamber (12). The control unit (50) is able to maintain a uniform pH during testing or to provide a dynamically adjustable pH during testing, for example to three or more different pH levels in order to test the performance of a drug carrier at different levels of acidity or alkalinity for example, mimicking the conditions of the gastrointestinal tract. The apparatus(20) and associated method are particularly suitable for testing and developing dosage forms for oral delivery of drugs.

KW - bicarboante buffer

KW - drug release

KW - Dissolution testing

KW - Invitro invivo correlation

UR - https://register.epo.org/application?number=EP13727316

UR - http://appft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220170108519%22.PGNR.&OS=DN/20170108519&RS=DN/20170108519

M3 - Patent

M1 - 2509286

ER -

Merchant H, Frost J, Basit A, inventors. Apparatus and method for testing medicaments. GB2509286. 2014 Jun 25.