Application of Polymer Combinations in Extended Release Hydrophilic Matrices

Ali Nokhodchi; Dasha Palmer; Kofi Asare-Addo; Marina Levina; Ali Rajabi-Siahboomi

doi:10.1002/9781119041375.ch2

Application of Polymer Combinations in Extended Release Hydrophilic Matrices

Ali Nokhodchi, Dasha Palmer, Kofi Asare-Addo, Marina Levina, Ali Rajabi-Siahboomi

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

6 Citations (Scopus)

Abstract

Extended release (ER) oral dosage forms provide a number of therapeutic benefits (i.e. improved efficacy, reduced frequency of administration and better patient compliance) and retain market share. Due to the costs involved in discovering, developing, testing their safety and getting approval for new polymeric materials, a new focus has been directed towards the investigation of the use of pharmaceutically approved polymer blends as matrix formers. Combining polymers of different chemistries or viscosities has been studied extensively as a means of achieving and optimising extended drug release from hydrophilic matrices. The present chapter will discuss the potential use of binary blends of various polymers to achieve the desirable release profiles.

Original language	English
Title of host publication	Handbook of Polymers for Pharmaceutical Technologies
Subtitle of host publication	Volume 1 Structure and Chemistry
Editors	Vijay Kumar Thakur, Manju Kumari Thakur
Publisher	Wiley
Pages	23-50
Number of pages	27
Volume	1
ISBN (Print)	9781119041344
DOIs	https://doi.org/10.1002/9781119041375.ch2
Publication status	Published - Aug 2015

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Application of Polymer Combinations in Extended Release Hydrophilic Matrices. / Nokhodchi, Ali; Palmer, Dasha; Asare-Addo, Kofi et al.

Handbook of Polymers for Pharmaceutical Technologies: Volume 1 Structure and Chemistry. ed. / Vijay Kumar Thakur; Manju Kumari Thakur. Vol. 1 Wiley, 2015. p. 23-50.

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

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AU - Levina, Marina

AU - Rajabi-Siahboomi, Ali

PY - 2015/8

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AB - Extended release (ER) oral dosage forms provide a number of therapeutic benefits (i.e. improved efficacy, reduced frequency of administration and better patient compliance) and retain market share. Due to the costs involved in discovering, developing, testing their safety and getting approval for new polymeric materials, a new focus has been directed towards the investigation of the use of pharmaceutically approved polymer blends as matrix formers. Combining polymers of different chemistries or viscosities has been studied extensively as a means of achieving and optimising extended drug release from hydrophilic matrices. The present chapter will discuss the potential use of binary blends of various polymers to achieve the desirable release profiles.

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Application of Polymer Combinations in Extended Release Hydrophilic Matrices

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