Approaches to the synthesis of non-racemic 3-substituted isoindolinone derivatives

Steven M. Allin, Christopher J. Northfield, Michael I. Page, Alexandra M.Z. Slawin

Research output: Contribution to journalArticlepeer-review

57 Citations (Scopus)


New methodology for the synthesis of non-racemic isoindolinone targets has been developed through application of tricyclic γ-lactam substrates as N-acyliminium ion precursors in reactions with carbon and hydride nucleophiles. Removal of the phenylglycinol derived chiral auxiliary can be achieved without loss of stereochemical integrity at the newly created asymmetric centre, and we report a novel method for this key step using conc. sulfuric acid.

Original languageEnglish
Pages (from-to)1715-1721
Number of pages7
JournalJournal of the Chemical Society, Perkin Transactions 1
Issue number11
Publication statusPublished - 2000


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