TY - JOUR
T1 - Ascorbic Acid as an Eco-friendly Catalyst for the Effcient Synthesis of Bis(3-methyl-1-phenyl-1H-pyrazol-5-ols) in Aqueous Media
AU - Gouda, Moustafa A.
AU - Elsherbini, Mohamed S.
AU - Helal, Mohamed H.
N1 - Publisher Copyright:
© 2020. Indian Journal of Heterocyclic Chemistry. All rights reserved.
Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2020/10/1
Y1 - 2020/10/1
N2 - One-pot, multi-component reaction of 3-methyl-1-phenyl-1H-pyrazol-5(4H)-one (1) and aryl aldehydes 2 or 5-substituted indoline-2,3-diones (4a-c) in the presence of ascorbic acid as a unique catalyst in aqueous media afforded the 4, 4’-(arylmethylene)-bis(3-methyl-1-phenyl-1H-pyrazol-5-ols) (3a-f) and 3, 3-bis-(5-hydroxy-3-methyl-1-phenyl-1H-pyrazol-4-yl)-5-substituted indolin-2-ones (5a-c), respectively. This protocol provides several advantages such as environmental friendliness, excellent yields, and simple workup procedure.
AB - One-pot, multi-component reaction of 3-methyl-1-phenyl-1H-pyrazol-5(4H)-one (1) and aryl aldehydes 2 or 5-substituted indoline-2,3-diones (4a-c) in the presence of ascorbic acid as a unique catalyst in aqueous media afforded the 4, 4’-(arylmethylene)-bis(3-methyl-1-phenyl-1H-pyrazol-5-ols) (3a-f) and 3, 3-bis-(5-hydroxy-3-methyl-1-phenyl-1H-pyrazol-4-yl)-5-substituted indolin-2-ones (5a-c), respectively. This protocol provides several advantages such as environmental friendliness, excellent yields, and simple workup procedure.
KW - 3-methyl-1-phenyl-1H-pyrazol-5(4H)-one
KW - 5-substituted indoline-2,3-diones
KW - aryl aldehydes
KW - ascorbic acid
KW - bis-(3-methyl-1-phenyl-1H-pyrazol-5-ol)
UR - http://www.scopus.com/inward/record.url?scp=85099925771&partnerID=8YFLogxK
UR - http://www.connectjournals.com/achivestoc.php?bookmark=CJ-001644&volume=30&year=2020&issue_id=04&issue_month=Oct-Dec#
M3 - Article
AN - SCOPUS:85099925771
VL - 30
SP - 559
EP - 563
JO - Indian Journal of Heterocyclic Chemistry
JF - Indian Journal of Heterocyclic Chemistry
SN - 0971-1627
IS - 4
ER -