Hot-spotting is a reliability problem influencing photovoltaic (PV) modules, where a mismatched solar cell/cells heat up significantly and reduce the output power of the affected PV module. Therefore, in this paper, a succinct comparison of seven different state-of-the-art maximum power point tracking (MPPT) techniques are demonstrated, doing useful comparisons with respect to amount of power extracted, and hence calculate their tracking accuracy. The MPPT techniques have been embedded into a commercial off-the-shelf MPPT unit, accordingly running different experiments on multiple hot-spotted PV modules. Furthermore, the comparison includes real-time long-term data measurements over several days and months of validation. Evidently, it was found that both fast changing MPPT and the modified beta techniques are best to use with PV modules affected by hot-spotted solar cells as well as during partial shading conditions, on average, their tracking accuracy ranging from 92% to 94%. Ultimately, the minimum tracking accuracy is below 93% obtained for direct pulsewwidth modulation voltage controller MPPT technique.