Association of a functional polymorphism in the adrenomedullin gene (ADM) with response to paroxetine

D M Glubb, P C McHugh, X Deng, P R Joyce, M A Kennedy

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

To identify genes that may be relevant to the molecular action of antidepressants, we investigated transcriptional changes induced by the selective serotonin reuptake inhibitor paroxetine in a serotonergic cell line. We examined gene expression changes after acute treatment with paroxetine and sought to validate microarray results by quantitative PCR (qPCR). Concordant transcriptional changes were confirmed for 14 genes by qPCR and five of these, including the adrenomedullin gene (Adm), either approached or reached statistical significance. Reporter gene assays showed that a SNP (rs11042725) in the upstream flanking region of ADM significantly altered expression. Association analysis demonstrated rs11042725 to be significantly associated with response to paroxetine (odds ratio=0.075, P<0.001) but not with response to either fluoxetine or citalopram. Our results suggest that ADM is involved with the therapeutic efficacy of paroxetine, which may have pharmacogenetic utility.
LanguageEnglish
Pages126-33
Number of pages8
JournalPharmacogenomics Journal
Volume10
Issue number2
DOIs
Publication statusPublished - 28 Jul 2009
Externally publishedYes

Fingerprint

Adrenomedullin
Paroxetine
Genes
Polymerase Chain Reaction
Citalopram
Fluoxetine
Pharmacogenetics
Serotonin Uptake Inhibitors
Reporter Genes
Antidepressive Agents
Single Nucleotide Polymorphism
Odds Ratio
Gene Expression
Cell Line

Cite this

Glubb, D M ; McHugh, P C ; Deng, X ; Joyce, P R ; Kennedy, M A. / Association of a functional polymorphism in the adrenomedullin gene (ADM) with response to paroxetine. In: Pharmacogenomics Journal. 2009 ; Vol. 10, No. 2. pp. 126-33.
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Association of a functional polymorphism in the adrenomedullin gene (ADM) with response to paroxetine. / Glubb, D M; McHugh, P C; Deng, X; Joyce, P R; Kennedy, M A.

In: Pharmacogenomics Journal, Vol. 10, No. 2, 28.07.2009, p. 126-33.

Research output: Contribution to journalArticle

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AU - Kennedy, M A

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