Asthma Inhaler Adherence in Adults: a Rapid Systematic Review with Meta-analysis

Amal Al Wadhahi, Loretta Garvey, John Stephenson, Karen Leigh Edward

Research output: Contribution to journalReview articlepeer-review


Objectives To undertake a rapid systematic review with meta-analysis of the interventions used to promote adherence to asthma medications in adults who have asthma. Methods Three databases (CINAHL, Web of Science, and Medline) were searched systematically up to February 2022 to identify the factors behind the non-adherent behavior of young adults with asthma using preventer medication. Manual searching was also undertaken to detect additional research. The team screened the titles and abstracts to ensure the eligibility of included studies. The full paper was retrieved for further screening and was extracted using an extraction tool. Results The literature search placed nine studies with a total sample number of 74540 were included in the three meta-analyses. Five studies were identified for inclusion in a meta-analysis conducted to assess the effect of the intervention on adherence. The meta-analysis revealed a significant difference in adherence proportion, in favor of the intervention. Conclusion Interventions delivered through technology were found to significantly enhance adults’ adherence to asthma medications. This review also revealed that there is an obvious gap in the literature that specifically examined young adults aged 18-34 years about asthma medication adherence. This demonstrates the need for robust future research to focus on this demographic (18-34yrs.) to develop recommendations related to enhancing young adults’ adherence to asthma inhaler medication.
Original languageEnglish
Article number84
Number of pages11
JournalSN Comprehensive Clinical Medicine
Publication statusPublished - 26 Mar 2022


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