Astragalus and human mesenchymal stem cells promote wound healing by mediating immunomodulatory effects through paracrine signaling

Jiaqi Wang; Dandan Zhang; Ying Zhu; Xiumei Mo; Patrick McHugh; Qiang Tong

doi:10.2217/rme-2021-0076

Astragalus and human mesenchymal stem cells promote wound healing by mediating immunomodulatory effects through paracrine signaling

Jiaqi Wang, Dandan Zhang, Ying Zhu, Xiumei Mo, Patrick McHugh, Qiang Tong

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

Background: Skin regeneration from an injury without a scar is still a challenge. Methods: A murine model of a skin wound was treated with a combination of extract of astragalus and exosomes of mesenchymal stem cells (MSCs). CD11b+ and CD45 macrophages were detected and levels of cytokines were tested. Results: The expression of growth factors VEGF, FGF2 and EGF was elevated after treatment administered to MSCs. The administration of ethanolic extract of astragalus decreased the expression of TNF-α, IL-1β and IL-6 and simultaneously increased the levels of IL-10. The combination sped up the process of wound healing. A sustained-release gel with both ingredients was developed to enhance restoration from granulation. Conclusion: The extract of astragalus promotes the efficacy of MSC-derived exosomes in skin repair.

Original language	English
Pages (from-to)	219-232
Number of pages	14
Journal	Regenerative Medicine
Volume	17
Issue number	4
Early online date	7 Mar 2022
DOIs	https://doi.org/10.2217/rme-2021-0076
Publication status	Published - 1 Apr 2022

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title = "Astragalus and human mesenchymal stem cells promote wound healing by mediating immunomodulatory effects through paracrine signaling",

abstract = "Background: Skin regeneration from an injury without a scar is still a challenge. Methods: A murine model of a skin wound was treated with a combination of extract of astragalus and exosomes of mesenchymal stem cells (MSCs). CD11b+ and CD45 macrophages were detected and levels of cytokines were tested. Results: The expression of growth factors VEGF, FGF2 and EGF was elevated after treatment administered to MSCs. The administration of ethanolic extract of astragalus decreased the expression of TNF-α, IL-1β and IL-6 and simultaneously increased the levels of IL-10. The combination sped up the process of wound healing. A sustained-release gel with both ingredients was developed to enhance restoration from granulation. Conclusion: The extract of astragalus promotes the efficacy of MSC-derived exosomes in skin repair.",

keywords = "ethanolic extract of astragalus, mesenchymal stem cells, wound healing, scar tissue, restoration, Ethanolic extract of astragalus, Scar tissue, Wound healing, Restoration, Mesenchymal stem cells",

author = "Jiaqi Wang and Dandan Zhang and Ying Zhu and Xiumei Mo and Patrick McHugh and Qiang Tong",

note = "Funding Information: This work was supported by the National Natural Science Foundation of China (Grant No. 81700069 and 81302580) and major project of Eighth Medical Center of Chinese PLA General Hospital (No. 2021ZD005). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. No writing assistance was utilized in the production of this manuscript. Publisher Copyright: {\textcopyright} 2022 Future Medicine Ltd.",

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doi = "10.2217/rme-2021-0076",

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AU - Wang, Jiaqi

AU - Zhang, Dandan

AU - Zhu, Ying

AU - Mo, Xiumei

AU - McHugh, Patrick

AU - Tong, Qiang

N1 - Funding Information: This work was supported by the National Natural Science Foundation of China (Grant No. 81700069 and 81302580) and major project of Eighth Medical Center of Chinese PLA General Hospital (No. 2021ZD005). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. No writing assistance was utilized in the production of this manuscript. Publisher Copyright: © 2022 Future Medicine Ltd.

PY - 2022/4/1

Y1 - 2022/4/1

N2 - Background: Skin regeneration from an injury without a scar is still a challenge. Methods: A murine model of a skin wound was treated with a combination of extract of astragalus and exosomes of mesenchymal stem cells (MSCs). CD11b+ and CD45 macrophages were detected and levels of cytokines were tested. Results: The expression of growth factors VEGF, FGF2 and EGF was elevated after treatment administered to MSCs. The administration of ethanolic extract of astragalus decreased the expression of TNF-α, IL-1β and IL-6 and simultaneously increased the levels of IL-10. The combination sped up the process of wound healing. A sustained-release gel with both ingredients was developed to enhance restoration from granulation. Conclusion: The extract of astragalus promotes the efficacy of MSC-derived exosomes in skin repair.

AB - Background: Skin regeneration from an injury without a scar is still a challenge. Methods: A murine model of a skin wound was treated with a combination of extract of astragalus and exosomes of mesenchymal stem cells (MSCs). CD11b+ and CD45 macrophages were detected and levels of cytokines were tested. Results: The expression of growth factors VEGF, FGF2 and EGF was elevated after treatment administered to MSCs. The administration of ethanolic extract of astragalus decreased the expression of TNF-α, IL-1β and IL-6 and simultaneously increased the levels of IL-10. The combination sped up the process of wound healing. A sustained-release gel with both ingredients was developed to enhance restoration from granulation. Conclusion: The extract of astragalus promotes the efficacy of MSC-derived exosomes in skin repair.

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KW - wound healing

KW - scar tissue

KW - restoration

KW - Ethanolic extract of astragalus

KW - Scar tissue

KW - Wound healing

KW - Restoration

KW - Mesenchymal stem cells

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Astragalus and human mesenchymal stem cells promote wound healing by mediating immunomodulatory effects through paracrine signaling

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