TY - JOUR
T1 - Author Response
T2 - Can Vascular Function Be Assessed by the Interpretation of Retinal Vascular Diameter Changes?
AU - Heitmar, Rebekka
AU - Blann, Andrew
AU - Cubbidge, Robert Peter
AU - Lip, Gregory
AU - Gherghel, Doina
N1 - Copyright:
Copyright 2011 Elsevier B.V., All rights reserved.
PY - 2011/1/1
Y1 - 2011/1/1
N2 - A protocol with repeated stimulation cycles should be analyzed stepwise, in that each stimulation is evaluated, and a reaction pattern is identified. No two subjects will react identically, in that dilation and recovery times can vary; however, this is not reason enough to abandon a multiple stimulation cycle with fixed recovery and stimulation times. Furthermore, it enables us to examine and determine the range in which a normal subject will be placed and can then be compared to different pathophysiological states (i.e., smokers and different diseases). The purpose of our paper was to highlight the importance of evaluating these different cycles and the danger of false interpretation when averaging results. There are many different ways of evaluating dilatory responses and elasticity, but each of them must be carefully evaluated and should not be overaveraged, which can result in a loss of sensitivity and specificity.
AB - A protocol with repeated stimulation cycles should be analyzed stepwise, in that each stimulation is evaluated, and a reaction pattern is identified. No two subjects will react identically, in that dilation and recovery times can vary; however, this is not reason enough to abandon a multiple stimulation cycle with fixed recovery and stimulation times. Furthermore, it enables us to examine and determine the range in which a normal subject will be placed and can then be compared to different pathophysiological states (i.e., smokers and different diseases). The purpose of our paper was to highlight the importance of evaluating these different cycles and the danger of false interpretation when averaging results. There are many different ways of evaluating dilatory responses and elasticity, but each of them must be carefully evaluated and should not be overaveraged, which can result in a loss of sensitivity and specificity.
KW - Analytical error
KW - Blood vessel diameter
KW - Blood vessel elasticity
KW - Blood vessel parameters
UR - http://www.scopus.com/inward/record.url?scp=79955991862&partnerID=8YFLogxK
U2 - 10.1167/iovs.10-6690
DO - 10.1167/iovs.10-6690
M3 - Letter
AN - SCOPUS:79955991862
VL - 52
SP - 636
EP - 638
JO - Investigative Ophthalmology and Visual Science
JF - Investigative Ophthalmology and Visual Science
SN - 0146-0404
IS - 1
ER -