Although there is much literature on the Transatlantic Slave Trade (TAST) and those concerning residents' perceptions of tourism development, it can be suggested that there remains a significant knowledge gap regarding attitudes and perceptions of residents towards the history of the TAST and the possible use of such resources for tourism development. This study attempts to address this gap by investigating residents' knowledge and attitude of developing tourism based on slave heritage in Danish-Osu, Ghana. Using a multi-stage sampling technique, 200 questionnaires were returned by residents in six communities in Danish-Osu. In addition, in-depth interviews and focus group discussions were conducted with interest groups and opinion leaders. Results of the research suggest that residents have an appreciable level of knowledge on the slave trade and related relics in their community. Most respondents indicated that they are comfortable living in the community which has an image of a former slave site. Majority identified tourism as the preferred means of conserving the existing slave sites and relics. Perceptions regarding utilization of slave relics were also found to significantly differ across a variety of socio-demographic indices. The study concludes by examining implications for Ghana's Slave Route Project to carve a niche for itself.