Behavior of In Situ Cross-Linked Hydrogels with Rapid Gelation Kinetics on Contact with Physiological Fluids

Ramadan Diryak; Vassilis Kontogiorgos; Muhammad U. Ghori; Paul Bills; Ahmed Tawfik; Gordon A. Morris; Alan Smith

doi:10.1002/macp.201700584

Behavior of In Situ Cross-Linked Hydrogels with Rapid Gelation Kinetics on Contact with Physiological Fluids

Ramadan Diryak, Vassilis Kontogiorgos, Muhammad U. Ghori, Paul Bills, Ahmed Tawfik, Gordon A. Morris, Alan Smith

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

The impact of different physiological fluids on the rheological properties of gellan gum is investigated using a commercially available rheometer with a modified lower plate. The power of this method is demonstrated by measuring in real time, the rapid gelation kinetics, and gel strength of gellan gum exposed to simulated gastric fluid, lacrimal fluid, saliva, and wound fluid (all having a different ionic composition), highlighting potential use in the intelligent design of in situ gelling delivery systems. Changes in rheological behavior are examined in situ, gelation kinetics are modeled, and microstructure analyzed in the different simulated physiological environments.

Original language	English
Article number	1700584
Number of pages	6
Journal	Macromolecular Chemistry and Physics
Volume	219
Issue number	8
Early online date	23 Feb 2018
DOIs	https://doi.org/10.1002/macp.201700584
Publication status	Published - 19 Apr 2018

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title = "Behavior of In Situ Cross-Linked Hydrogels with Rapid Gelation Kinetics on Contact with Physiological Fluids",

abstract = "The impact of different physiological fluids on the rheological properties of gellan gum is investigated using a commercially available rheometer with a modified lower plate. The power of this method is demonstrated by measuring in real time, the rapid gelation kinetics, and gel strength of gellan gum exposed to simulated gastric fluid, lacrimal fluid, saliva, and wound fluid (all having a different ionic composition), highlighting potential use in the intelligent design of in situ gelling delivery systems. Changes in rheological behavior are examined in situ, gelation kinetics are modeled, and microstructure analyzed in the different simulated physiological environments.",

keywords = "biopolymers, delivery systems, gelation, physiologically responsive, rheology",

author = "Ramadan Diryak and Vassilis Kontogiorgos and Ghori, {Muhammad U.} and Paul Bills and Ahmed Tawfik and Morris, {Gordon A.} and Alan Smith",

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AU - Diryak, Ramadan

AU - Kontogiorgos, Vassilis

AU - Ghori, Muhammad U.

AU - Bills, Paul

AU - Tawfik, Ahmed

AU - Morris, Gordon A.

AU - Smith, Alan

PY - 2018/4/19

Y1 - 2018/4/19

N2 - The impact of different physiological fluids on the rheological properties of gellan gum is investigated using a commercially available rheometer with a modified lower plate. The power of this method is demonstrated by measuring in real time, the rapid gelation kinetics, and gel strength of gellan gum exposed to simulated gastric fluid, lacrimal fluid, saliva, and wound fluid (all having a different ionic composition), highlighting potential use in the intelligent design of in situ gelling delivery systems. Changes in rheological behavior are examined in situ, gelation kinetics are modeled, and microstructure analyzed in the different simulated physiological environments.

AB - The impact of different physiological fluids on the rheological properties of gellan gum is investigated using a commercially available rheometer with a modified lower plate. The power of this method is demonstrated by measuring in real time, the rapid gelation kinetics, and gel strength of gellan gum exposed to simulated gastric fluid, lacrimal fluid, saliva, and wound fluid (all having a different ionic composition), highlighting potential use in the intelligent design of in situ gelling delivery systems. Changes in rheological behavior are examined in situ, gelation kinetics are modeled, and microstructure analyzed in the different simulated physiological environments.

KW - biopolymers

KW - delivery systems

KW - gelation

KW - physiologically responsive

KW - rheology

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VL - 219

JO - Macromolecular Chemistry and Physics

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SN - 1022-1352

IS - 8

M1 - 1700584

ER -

Behavior of In Situ Cross-Linked Hydrogels with Rapid Gelation Kinetics on Contact with Physiological Fluids

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Gordon Morris

ESPRC Centre for Innovative Manufacturing in Advanced Metrology

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Behavior of In Situ Cross-Linked Hydrogels with Rapid Gelation Kinetics on Contact with Physiological Fluids

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ESPRC Centre for Innovative Manufacturing in Advanced Metrology

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