Abstract

The impact of different physiological fluids on the rheological properties of gellan gum is investigated using a commercially available rheometer with a modified lower plate. The power of this method is demonstrated by measuring in real time, the rapid gelation kinetics, and gel strength of gellan gum exposed to simulated gastric fluid, lacrimal fluid, saliva, and wound fluid (all having a different ionic composition), highlighting potential use in the intelligent design of in situ gelling delivery systems. Changes in rheological behavior are examined in situ, gelation kinetics are modeled, and microstructure analyzed in the different simulated physiological environments.
Original languageEnglish
Article number1700584
Number of pages6
JournalMacromolecular Chemistry and Physics
Volume219
Issue number8
Early online date23 Feb 2018
DOIs
Publication statusPublished - Apr 2018

Fingerprint

Hydrogels
gelation
Gelation
Contacts (fluid mechanics)
Kinetics
Fluids
fluids
kinetics
saliva
rheometers
Rheometers
delivery
Gels
gels
microstructure
Microstructure
Chemical analysis
gellan gum

Cite this

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title = "Behavior of In Situ Cross-Linked Hydrogels with Rapid Gelation Kinetics on Contact with Physiological Fluids",
abstract = "The impact of different physiological fluids on the rheological properties of gellan gum is investigated using a commercially available rheometer with a modified lower plate. The power of this method is demonstrated by measuring in real time, the rapid gelation kinetics, and gel strength of gellan gum exposed to simulated gastric fluid, lacrimal fluid, saliva, and wound fluid (all having a different ionic composition), highlighting potential use in the intelligent design of in situ gelling delivery systems. Changes in rheological behavior are examined in situ, gelation kinetics are modeled, and microstructure analyzed in the different simulated physiological environments.",
keywords = "biopolymers, delivery systems, gelation, physiologically responsive, rheology",
author = "Ramadan Diryak and Vassilis Kontogiorgos and Ghori, {Muhammad U.} and Paul Bills and Ahmed Tawfik and Morris, {Gordon A.} and Alan Smith",
year = "2018",
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language = "English",
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Behavior of In Situ Cross-Linked Hydrogels with Rapid Gelation Kinetics on Contact with Physiological Fluids. / Diryak, Ramadan; Kontogiorgos, Vassilis; Ghori, Muhammad U.; Bills, Paul; Tawfik, Ahmed; Morris, Gordon A.; Smith, Alan.

In: Macromolecular Chemistry and Physics, Vol. 219, No. 8, 1700584, 04.2018.

Research output: Contribution to journalArticle

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AU - Diryak, Ramadan

AU - Kontogiorgos, Vassilis

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AU - Tawfik, Ahmed

AU - Morris, Gordon A.

AU - Smith, Alan

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KW - biopolymers

KW - delivery systems

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