Biocatalysis-coupled cell growth process in 1,3-propanediol production by Klebsiella pneumoniae

Chenyu Du, Chun Li, Dong Yang, Yanping Zhang, Zhu'an Cao

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


This paper focuses on the research of the bioconversion of 1,3-propanediol by Klebsiella pneumoniae. The linear correlation of cell growth and 1,3-propanediol synthesis was found. An equation of the relationship between cell growth and biocatalysis was given. With the analysis of metabolism, it was discovered that the cell regulated the NADH production by cell growth in order to supply enough reductive equivalent for enzyme catalysis. A conclusion was drawn that the cell growth was coupled with the reactivation of a key-enzyme which catalyzes 1,3-propanediol production in Klebsiella pneumoniae.

Original languageEnglish
Pages (from-to)505-508
Number of pages4
JournalHuagong Xuebao/Journal of Chemical Industry and Engineering (China)
Issue number3
Publication statusPublished - 1 Mar 2004
Externally publishedYes


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