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Keyphrases
Bioreductive Activation
100%
Structure-activity Relationship
100%
Indolequinone
100%
DT-diaphorase
100%
Substrate Specificity
66%
DNA Damage
33%
Mechanism of Action
16%
Cytotoxicity
16%
Aerobic Conditions
16%
Single-strand DNA Breaks
16%
Hypoxia-selective
16%
NAD(P)
16%
Functional Groups
16%
Amino Acids
16%
Binding Site
16%
Active Sites
16%
Methyl
16%
Hydrogen Peroxide
16%
Alkylation
16%
Molecular Modeling Studies
16%
Quinone Oxidoreductase
16%
Molecular Features
16%
Relay Mechanism
16%
Minor Change
16%
Leaving Group
16%
Catalase
16%
Substrate-induced
16%
Redox Mechanism
16%
Indole-2-carboxamide
16%
Chlorine Atom
16%
Indol
16%
Cell-free Assay
16%
Hydrogen Production
16%
Charge Relay
16%
Selectivity Enhancement
16%
Pharmacology, Toxicology and Pharmaceutical Science
Structure Activity Relationship
100%
Reduced Nicotinamide Adenine Dinucleotide (Phosphate) Dehydrogenase (Quinone)
100%
Indole Derivative
100%
Substrate Specificity
57%
Indole
28%
Cytotoxicity
14%
Hypoxia
14%
Single Stranded DNA
14%
Functional Group
14%
Hydrogen Peroxide
14%
Binding Site
14%
Carboxamide
14%
Amino Acid
14%
Catalase
14%
Biochemistry, Genetics and Molecular Biology
Structure Activity Relation
100%
Dihydrolipoamide Dehydrogenase
100%
Enzyme Specificity
66%
Cytotoxicity
16%
Oxidoreductase
16%
DNA Damage
16%
Binding Site
16%
Active Site
16%
Hydrogen Peroxide
16%
Molecular Model
16%
Amino Acid
16%
Catalase
16%
Alkylation
16%
Single-Strand DNA Break
16%