TY - JOUR
T1 - Biosurfactants as foaming agents in calcium phosphate bone cements
AU - Cichoń, Ewelina
AU - Czechowska, Joanna
AU - Krok-Borkowicz, Małgorzata
AU - Allinson, Sarah L.
AU - Stępień, Karolina
AU - Smith, Alan
AU - Pamuła, Elżbieta
AU - Douglas, Timothy E. L.
AU - Zima, Aneta
N1 - Funding Information:
This study was supported by the National Science Centre, Poland (Project No. 2017/27/N/ST8/00913 ), by the subvention from the Ministry of Science and Higher Education (Poland) for the Faculty of Materials Science and Ceramics AGH UST – University of Science and Technology, Krakow, Poland, Project No. 16.16.160.557 (2022) and partially by the Program “Excellent Initiative – Research University” for the AGH University of Science and Technology. E. C. acknowledges financial support from the National Science Centre, Poland under Doctoral Scholarship No. 2019/32/T/ST5/00207 . The authors would like to thank Prof. Jacek Tarasiuk (AGH University of Science and Technology, Poland) for materials analysis by computer microtomography and Dr. Elisabeth Shaw and Dr. Alexandre Benedetto (Lancaster University, UK) for materials imaging with a fluorescence microscope.
Publisher Copyright:
© 2022 Elsevier B.V.
PY - 2023/2/1
Y1 - 2023/2/1
N2 - The idea of using biosurfactants to obtain highly porous, foamed calcium phosphate cements (fCPCs) is novel. The popularity of these compounds is mainly attributed to their biological activity such as anticancer or antibacterial properties. In our study, it was investigated how the functionalization of cements, based on α-tricalcium phosphate (α-TCP), with non-ionic biosurfactants such as sucrose ester S0112 and saponin from Quillaja bark affected the physicochemical as well as biological properties of cement-type materials. Foaming with these selected surface active agents led to highly porous fCPCs (open porosity >60 vol%) with compressive strength values ranging from 0.2 to 3.3 MPa and did not influence negatively the bioactive potential of the cements. Results showed that the sucrose ester had a positive effect on all studied cell types (osteosarcoma cell line MG-63 and preosteoblasts MC3T3-E1), while the effect of the saponin differed depending on the origin of the cells (cancerous or non-cancerous). The obtained results shed new light on the use of biosurfactants as additives to CPCs and pave the way for further studies, especially in vivo.
AB - The idea of using biosurfactants to obtain highly porous, foamed calcium phosphate cements (fCPCs) is novel. The popularity of these compounds is mainly attributed to their biological activity such as anticancer or antibacterial properties. In our study, it was investigated how the functionalization of cements, based on α-tricalcium phosphate (α-TCP), with non-ionic biosurfactants such as sucrose ester S0112 and saponin from Quillaja bark affected the physicochemical as well as biological properties of cement-type materials. Foaming with these selected surface active agents led to highly porous fCPCs (open porosity >60 vol%) with compressive strength values ranging from 0.2 to 3.3 MPa and did not influence negatively the bioactive potential of the cements. Results showed that the sucrose ester had a positive effect on all studied cell types (osteosarcoma cell line MG-63 and preosteoblasts MC3T3-E1), while the effect of the saponin differed depending on the origin of the cells (cancerous or non-cancerous). The obtained results shed new light on the use of biosurfactants as additives to CPCs and pave the way for further studies, especially in vivo.
KW - Bone cements
KW - Biosurfactants
KW - Calcium phosphates
KW - Porosity
KW - Nonionic surfactants
UR - http://www.scopus.com/inward/record.url?scp=85145975613&partnerID=8YFLogxK
U2 - 10.1016/j.bioadv.2022.213273
DO - 10.1016/j.bioadv.2022.213273
M3 - Article
VL - 145
JO - Biomaterials Advances
JF - Biomaterials Advances
SN - 2772-9508
M1 - 213273
ER -
