C. elegans Kallmann syndrome protein KAL-1 interacts with syndecan and glypican to regulate neuronal cell migrations

Martin L. Hudson, Tarja Kinnunen, Hediye Nese Cinar, Andrew D. Chisholm

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

The anosmin-1 protein family regulates cell migration, axon guidance, and branching, by mechanisms that are not well understood. We show that the C. elegans anosmin-1 ortholog KAL-1 promotes migrations of ventral neuroblasts prior to epidermal enclosure. KAL-1 does not modulate FGF signaling in neuroblast migration and acts in parallel to other neuroblast migration pathways. Defects in heparan sulfate (HS) synthesis or in specific HS modifications disrupt neuroblast migrations and affect the KAL-1 pathway. KAL-1 binds the cell surface HS proteoglycans syndecan/SDN-1 and glypican/GPN-1. This interaction is mediated via HS side chains and requires specific HS modifications. SDN-1 and GPN-1 are expressed in ventral neuroblasts and have redundant roles in KAL-1-dependent neuroblast migrations. Our findings suggest that KAL-1 interacts with multiple HSPGs to promote cell migration.

LanguageEnglish
Pages352-365
Number of pages14
JournalDevelopmental Biology
Volume294
Issue number2
Early online date3 May 2006
DOIs
Publication statusPublished - 15 Jun 2006
Externally publishedYes

Fingerprint

Syndecans
Glypicans
Heparitin Sulfate
Cell Movement
Heparan Sulfate Proteoglycans
Syndecan-1
C elegans KAL-1 protein
Proteins

Cite this

Hudson, Martin L. ; Kinnunen, Tarja ; Cinar, Hediye Nese ; Chisholm, Andrew D. / C. elegans Kallmann syndrome protein KAL-1 interacts with syndecan and glypican to regulate neuronal cell migrations. In: Developmental Biology. 2006 ; Vol. 294, No. 2. pp. 352-365.
@article{f1bae58d2ab648c4887a6874363b6d44,
title = "C. elegans Kallmann syndrome protein KAL-1 interacts with syndecan and glypican to regulate neuronal cell migrations",
abstract = "The anosmin-1 protein family regulates cell migration, axon guidance, and branching, by mechanisms that are not well understood. We show that the C. elegans anosmin-1 ortholog KAL-1 promotes migrations of ventral neuroblasts prior to epidermal enclosure. KAL-1 does not modulate FGF signaling in neuroblast migration and acts in parallel to other neuroblast migration pathways. Defects in heparan sulfate (HS) synthesis or in specific HS modifications disrupt neuroblast migrations and affect the KAL-1 pathway. KAL-1 binds the cell surface HS proteoglycans syndecan/SDN-1 and glypican/GPN-1. This interaction is mediated via HS side chains and requires specific HS modifications. SDN-1 and GPN-1 are expressed in ventral neuroblasts and have redundant roles in KAL-1-dependent neuroblast migrations. Our findings suggest that KAL-1 interacts with multiple HSPGs to promote cell migration.",
keywords = "Anosmin, Ephrin, Glypican, Heparan sulfate proteoglycan, Kallmann syndrome, Morphogenesis, Syndecan",
author = "Hudson, {Martin L.} and Tarja Kinnunen and Cinar, {Hediye Nese} and Chisholm, {Andrew D.}",
year = "2006",
month = "6",
day = "15",
doi = "10.1016/j.ydbio.2006.02.036",
language = "English",
volume = "294",
pages = "352--365",
journal = "Developmental Biology",
issn = "0012-1606",
publisher = "Academic Press Inc.",
number = "2",

}

C. elegans Kallmann syndrome protein KAL-1 interacts with syndecan and glypican to regulate neuronal cell migrations. / Hudson, Martin L.; Kinnunen, Tarja; Cinar, Hediye Nese; Chisholm, Andrew D.

In: Developmental Biology, Vol. 294, No. 2, 15.06.2006, p. 352-365.

Research output: Contribution to journalArticle

TY - JOUR

T1 - C. elegans Kallmann syndrome protein KAL-1 interacts with syndecan and glypican to regulate neuronal cell migrations

AU - Hudson, Martin L.

AU - Kinnunen, Tarja

AU - Cinar, Hediye Nese

AU - Chisholm, Andrew D.

PY - 2006/6/15

Y1 - 2006/6/15

N2 - The anosmin-1 protein family regulates cell migration, axon guidance, and branching, by mechanisms that are not well understood. We show that the C. elegans anosmin-1 ortholog KAL-1 promotes migrations of ventral neuroblasts prior to epidermal enclosure. KAL-1 does not modulate FGF signaling in neuroblast migration and acts in parallel to other neuroblast migration pathways. Defects in heparan sulfate (HS) synthesis or in specific HS modifications disrupt neuroblast migrations and affect the KAL-1 pathway. KAL-1 binds the cell surface HS proteoglycans syndecan/SDN-1 and glypican/GPN-1. This interaction is mediated via HS side chains and requires specific HS modifications. SDN-1 and GPN-1 are expressed in ventral neuroblasts and have redundant roles in KAL-1-dependent neuroblast migrations. Our findings suggest that KAL-1 interacts with multiple HSPGs to promote cell migration.

AB - The anosmin-1 protein family regulates cell migration, axon guidance, and branching, by mechanisms that are not well understood. We show that the C. elegans anosmin-1 ortholog KAL-1 promotes migrations of ventral neuroblasts prior to epidermal enclosure. KAL-1 does not modulate FGF signaling in neuroblast migration and acts in parallel to other neuroblast migration pathways. Defects in heparan sulfate (HS) synthesis or in specific HS modifications disrupt neuroblast migrations and affect the KAL-1 pathway. KAL-1 binds the cell surface HS proteoglycans syndecan/SDN-1 and glypican/GPN-1. This interaction is mediated via HS side chains and requires specific HS modifications. SDN-1 and GPN-1 are expressed in ventral neuroblasts and have redundant roles in KAL-1-dependent neuroblast migrations. Our findings suggest that KAL-1 interacts with multiple HSPGs to promote cell migration.

KW - Anosmin

KW - Ephrin

KW - Glypican

KW - Heparan sulfate proteoglycan

KW - Kallmann syndrome

KW - Morphogenesis

KW - Syndecan

UR - http://www.scopus.com/inward/record.url?scp=33744969509&partnerID=8YFLogxK

U2 - 10.1016/j.ydbio.2006.02.036

DO - 10.1016/j.ydbio.2006.02.036

M3 - Article

VL - 294

SP - 352

EP - 365

JO - Developmental Biology

T2 - Developmental Biology

JF - Developmental Biology

SN - 0012-1606

IS - 2

ER -