C-Peptide

Connecting diabetes with macrovascular complications

Karen E. Porter, Romana S. Mughal

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

The incidence of diabetes is increasing globally; the estimated prevalence in 2010 being 285 million worldwide (www.http://diabetes.org.uk). In the UK alone, the number of people diagnosed with diabetes has increased from 1.4 to 2.6 million since 1996 (www.http://diabetes.org.uk). These individuals are at high risk of cardiovascular disease and in this population coronary artery disease (CAD) is common, regularly manifesting itself earlier in life than in individuals without diabetes [1]. While strategies that maintain tight glucose control have been reported to ameliorate some of the microvascular complications of diabetes (retinopathy, nephropathy, neuropathy) [2], this approach appears to have little or no benefit in the macrovasculature [3]. A greater understanding of the complexity of the diabetic milieu may therefore be invaluable in exposing therapeutic targets to reduce the incidence of macrovascular diseases in diabetes.
Original languageEnglish
Title of host publicationDiabetes & C-Peptide: Scientific and Clinical Aspects
EditorsAnders A.F. Sima
PublisherHumana Press Inc.
Pages129-144
Number of pages16
ISBN (Electronic)9781617793912
ISBN (Print)9781617793905
DOIs
Publication statusPublished - 28 Oct 2011
Externally publishedYes

Fingerprint

C-Peptide
Incidence
Diabetes Complications
Type 1 Diabetes Mellitus
Coronary Artery Disease
Cardiovascular Diseases
Glucose
Population
Therapeutics

Cite this

Porter, K. E., & Mughal, R. S. (2011). C-Peptide: Connecting diabetes with macrovascular complications. In A. A. F. Sima (Ed.), Diabetes & C-Peptide: Scientific and Clinical Aspects (pp. 129-144). Humana Press Inc.. https://doi.org/10.1007/978-1-61779-391-2_11
Porter, Karen E. ; Mughal, Romana S. / C-Peptide : Connecting diabetes with macrovascular complications. Diabetes & C-Peptide: Scientific and Clinical Aspects. editor / Anders A.F. Sima. Humana Press Inc., 2011. pp. 129-144
@inbook{1c10f557ca094c0ea0ecd13f6bfb4f30,
title = "C-Peptide: Connecting diabetes with macrovascular complications",
abstract = "The incidence of diabetes is increasing globally; the estimated prevalence in 2010 being 285 million worldwide (www.http://diabetes.org.uk). In the UK alone, the number of people diagnosed with diabetes has increased from 1.4 to 2.6 million since 1996 (www.http://diabetes.org.uk). These individuals are at high risk of cardiovascular disease and in this population coronary artery disease (CAD) is common, regularly manifesting itself earlier in life than in individuals without diabetes [1]. While strategies that maintain tight glucose control have been reported to ameliorate some of the microvascular complications of diabetes (retinopathy, nephropathy, neuropathy) [2], this approach appears to have little or no benefit in the macrovasculature [3]. A greater understanding of the complexity of the diabetic milieu may therefore be invaluable in exposing therapeutic targets to reduce the incidence of macrovascular diseases in diabetes.",
keywords = "Coronary heart disease, Endothelial cell, Mechanisms, Revascularisation, Smooth muscle cell",
author = "Porter, {Karen E.} and Mughal, {Romana S.}",
year = "2011",
month = "10",
day = "28",
doi = "10.1007/978-1-61779-391-2_11",
language = "English",
isbn = "9781617793905",
pages = "129--144",
editor = "Sima, {Anders A.F.}",
booktitle = "Diabetes & C-Peptide: Scientific and Clinical Aspects",
publisher = "Humana Press Inc.",

}

Porter, KE & Mughal, RS 2011, C-Peptide: Connecting diabetes with macrovascular complications. in AAF Sima (ed.), Diabetes & C-Peptide: Scientific and Clinical Aspects. Humana Press Inc., pp. 129-144. https://doi.org/10.1007/978-1-61779-391-2_11

C-Peptide : Connecting diabetes with macrovascular complications. / Porter, Karen E.; Mughal, Romana S.

Diabetes & C-Peptide: Scientific and Clinical Aspects. ed. / Anders A.F. Sima. Humana Press Inc., 2011. p. 129-144.

Research output: Chapter in Book/Report/Conference proceedingChapter

TY - CHAP

T1 - C-Peptide

T2 - Connecting diabetes with macrovascular complications

AU - Porter, Karen E.

AU - Mughal, Romana S.

PY - 2011/10/28

Y1 - 2011/10/28

N2 - The incidence of diabetes is increasing globally; the estimated prevalence in 2010 being 285 million worldwide (www.http://diabetes.org.uk). In the UK alone, the number of people diagnosed with diabetes has increased from 1.4 to 2.6 million since 1996 (www.http://diabetes.org.uk). These individuals are at high risk of cardiovascular disease and in this population coronary artery disease (CAD) is common, regularly manifesting itself earlier in life than in individuals without diabetes [1]. While strategies that maintain tight glucose control have been reported to ameliorate some of the microvascular complications of diabetes (retinopathy, nephropathy, neuropathy) [2], this approach appears to have little or no benefit in the macrovasculature [3]. A greater understanding of the complexity of the diabetic milieu may therefore be invaluable in exposing therapeutic targets to reduce the incidence of macrovascular diseases in diabetes.

AB - The incidence of diabetes is increasing globally; the estimated prevalence in 2010 being 285 million worldwide (www.http://diabetes.org.uk). In the UK alone, the number of people diagnosed with diabetes has increased from 1.4 to 2.6 million since 1996 (www.http://diabetes.org.uk). These individuals are at high risk of cardiovascular disease and in this population coronary artery disease (CAD) is common, regularly manifesting itself earlier in life than in individuals without diabetes [1]. While strategies that maintain tight glucose control have been reported to ameliorate some of the microvascular complications of diabetes (retinopathy, nephropathy, neuropathy) [2], this approach appears to have little or no benefit in the macrovasculature [3]. A greater understanding of the complexity of the diabetic milieu may therefore be invaluable in exposing therapeutic targets to reduce the incidence of macrovascular diseases in diabetes.

KW - Coronary heart disease

KW - Endothelial cell

KW - Mechanisms

KW - Revascularisation

KW - Smooth muscle cell

UR - http://www.scopus.com/inward/record.url?scp=84939220616&partnerID=8YFLogxK

U2 - 10.1007/978-1-61779-391-2_11

DO - 10.1007/978-1-61779-391-2_11

M3 - Chapter

SN - 9781617793905

SP - 129

EP - 144

BT - Diabetes & C-Peptide: Scientific and Clinical Aspects

A2 - Sima, Anders A.F.

PB - Humana Press Inc.

ER -

Porter KE, Mughal RS. C-Peptide: Connecting diabetes with macrovascular complications. In Sima AAF, editor, Diabetes & C-Peptide: Scientific and Clinical Aspects. Humana Press Inc. 2011. p. 129-144 https://doi.org/10.1007/978-1-61779-391-2_11