Calorimetric investigations of the hydrolytic degradation for a series of β-sultams

Research output: Contribution to journalArticle

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Abstract

The hydrolytic degradation of four β-sultams was investigated using isothermal microcalorimetry to determine kinetic and enthalpic data. Firstly, all four compounds were analysed in the solid-state at 310 K, with a significant substituent-based stabilising/destabilising effect being observed. Secondly, the four compounds were analysed in the presence of pH 4 acetate buffer, at three temperatures (298, 310 and 323 K). Under these conditions, the substituent choice affected the rate of hydrolysis and the associated change in enthalpy for each compound. Based on the calorimetric data presented in this work, no change in reaction mechanism for the hydrolytic degradation was observed over the temperature range considered.

Original languageEnglish
Pages (from-to)339-342
Number of pages4
JournalJournal of Thermal Analysis and Calorimetry
Volume93
Issue number2
Early online date26 Jan 2008
DOIs
Publication statusPublished - 1 Aug 2008

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degradation
Degradation
hydrolysis
acetates
Enthalpy
Hydrolysis
Buffers
Acetates
buffers
enthalpy
solid state
Temperature
Kinetics
temperature
kinetics
naphthosultone

Cite this

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title = "Calorimetric investigations of the hydrolytic degradation for a series of β-sultams",
abstract = "The hydrolytic degradation of four β-sultams was investigated using isothermal microcalorimetry to determine kinetic and enthalpic data. Firstly, all four compounds were analysed in the solid-state at 310 K, with a significant substituent-based stabilising/destabilising effect being observed. Secondly, the four compounds were analysed in the presence of pH 4 acetate buffer, at three temperatures (298, 310 and 323 K). Under these conditions, the substituent choice affected the rate of hydrolysis and the associated change in enthalpy for each compound. Based on the calorimetric data presented in this work, no change in reaction mechanism for the hydrolytic degradation was observed over the temperature range considered.",
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Calorimetric investigations of the hydrolytic degradation for a series of β-sultams. / Waters, L. J.; Naz, S.; Hemming, K.

In: Journal of Thermal Analysis and Calorimetry, Vol. 93, No. 2, 01.08.2008, p. 339-342.

Research output: Contribution to journalArticle

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